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    Enox2 ecto-NOX disulfide-thiol exchanger 2 [ Mus musculus (house mouse) ]

    Gene ID: 209224, updated on 27-Nov-2024

    Summary

    Official Symbol
    Enox2provided by MGI
    Official Full Name
    ecto-NOX disulfide-thiol exchanger 2provided by MGI
    Primary source
    MGI:MGI:2384799
    See related
    Ensembl:ENSMUSG00000031109 AllianceGenome:MGI:2384799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APK1; tNOX; Cova1
    Summary
    Predicted to enable RNA binding activity and oxidoreductase activity. Predicted to be involved in electron transport chain and ultradian rhythm. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; olfactory epithelium; and retina. Orthologous to human ENOX2 (ecto-NOX disulfide-thiol exchanger 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1.8), bladder adult (RPKM 1.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Enox2 in Genome Data Viewer
    Location:
    X A5; X 25.79 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (48098584..48377126, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (49009707..49288243, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47128 Neighboring gene fibrous sheath-interacting protein 2-like Neighboring gene predicted gene, 35107 Neighboring gene STARR-seq mESC enhancer starr_47129 Neighboring gene predicted gene, 35210 Neighboring gene STARR-seq mESC enhancer starr_47130 Neighboring gene STARR-seq mESC enhancer starr_47131 Neighboring gene STARR-positive B cell enhancer mm9_chrX:46641346-46641647 Neighboring gene predicted gene, 39513 Neighboring gene predicted gene 14696 Neighboring gene Rho GTPase activating protein 36

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC32453

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in electron transport chain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in electron transport chain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ultradian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ultradian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ecto-NOX disulfide-thiol exchanger 2
    Names
    APK1 antigen
    cytosolic ovarian carcinoma antigen 1
    tumor-associated hydroquinone oxidase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271447.1NP_001258376.1  ecto-NOX disulfide-thiol exchanger 2 isoform a

      See identical proteins and their annotated locations for NP_001258376.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, 3, and 4 encode the same isoform (a).
      Source sequence(s)
      AK041822, AK137736, BX294194
      Consensus CDS
      CCDS30115.1
      UniProtKB/Swiss-Prot
      B1B073, Q8BY59, Q8R0Z2, Q8R372
      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Related
      ENSMUSP00000110568.3, ENSMUST00000114918.9
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    2. NM_001271448.1NP_001258377.1  ecto-NOX disulfide-thiol exchanger 2 isoform a

      See identical proteins and their annotated locations for NP_001258377.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
      Source sequence(s)
      AK041822, AK133956, BX294194
      Consensus CDS
      CCDS30115.1
      UniProtKB/Swiss-Prot
      B1B073, Q8BY59, Q8R0Z2, Q8R372
      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Related
      ENSMUSP00000128885.2, ENSMUST00000167659.8
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    3. NM_001271449.1NP_001258378.1  ecto-NOX disulfide-thiol exchanger 2 isoform a

      See identical proteins and their annotated locations for NP_001258378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
      Source sequence(s)
      AK041822, AK137736, BX005279, BX294194
      Consensus CDS
      CCDS30115.1
      UniProtKB/Swiss-Prot
      B1B073, Q8BY59, Q8R0Z2, Q8R372
      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Related
      ENSMUSP00000110564.2, ENSMUST00000114914.8
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    4. NM_001271450.1NP_001258379.1  ecto-NOX disulfide-thiol exchanger 2 isoform b

      See identical proteins and their annotated locations for NP_001258379.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK041822, BX294194
      Consensus CDS
      CCDS72378.1
      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Related
      ENSMUSP00000110561.2, ENSMUST00000114911.8
      Conserved Domains (2) summary
      COG0724
      Location:90168
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    5. NM_001271451.1NP_001258380.1  ecto-NOX disulfide-thiol exchanger 2 isoform c

      See identical proteins and their annotated locations for NP_001258380.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AK028343, AK133956, BX294194
      Consensus CDS
      CCDS72377.1
      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Related
      ENSMUSP00000110562.2, ENSMUST00000114912.8
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    6. NM_145951.5NP_666063.1  ecto-NOX disulfide-thiol exchanger 2 isoform a

      See identical proteins and their annotated locations for NP_666063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
      Source sequence(s)
      AK034058, AK133956, BX294194
      Consensus CDS
      CCDS30115.1
      UniProtKB/Swiss-Prot
      B1B073, Q8BY59, Q8R0Z2, Q8R372
      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Related
      ENSMUSP00000033437.9, ENSMUST00000033437.15
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      48098584..48377126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161893.1XP_036017786.1  ecto-NOX disulfide-thiol exchanger 2 isoform X17

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    2. XM_011250994.3XP_011249296.2  ecto-NOX disulfide-thiol exchanger 2 isoform X6

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:164247
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    3. XM_030251287.2XP_030107147.1  ecto-NOX disulfide-thiol exchanger 2 isoform X13

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:164247
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    4. XM_011250995.3XP_011249297.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:164247
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    5. XM_017318449.3XP_017173938.1  ecto-NOX disulfide-thiol exchanger 2 isoform X2

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:164247
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    6. XM_011250996.3XP_011249298.1  ecto-NOX disulfide-thiol exchanger 2 isoform X8

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (2) summary
      cd12228
      Location:164247
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02169
      Location:448567
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    7. XM_011250992.4XP_011249294.1  ecto-NOX disulfide-thiol exchanger 2 isoform X1

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (2) summary
      cd12228
      Location:164247
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02169
      Location:448567
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    8. XM_030251285.2XP_030107145.1  ecto-NOX disulfide-thiol exchanger 2 isoform X7

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:161244
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    9. XM_017318451.3XP_017173940.1  ecto-NOX disulfide-thiol exchanger 2 isoform X4

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:161244
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    10. XM_011251000.4XP_011249302.2  ecto-NOX disulfide-thiol exchanger 2 isoform X16

      UniProtKB/Swiss-Prot
      B1B073, Q8BY59, Q8R0Z2, Q8R372
      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    11. XM_036161888.1XP_036017781.1  ecto-NOX disulfide-thiol exchanger 2 isoform X14

      UniProtKB/TrEMBL
      A0AAQ4VMU9, Q3UT06, Q3UUZ1, Q3UZA6
      Related
      ENSMUSP00000159994.1, ENSMUST00000249897.1
      Conserved Domains (1) summary
      cd12228
      Location:113196
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    12. XM_036161890.1XP_036017783.1  ecto-NOX disulfide-thiol exchanger 2 isoform X16

      UniProtKB/Swiss-Prot
      B1B073, Q8BY59, Q8R0Z2, Q8R372
      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    13. XM_036161891.1XP_036017784.1  ecto-NOX disulfide-thiol exchanger 2 isoform X16

      UniProtKB/Swiss-Prot
      B1B073, Q8BY59, Q8R0Z2, Q8R372
      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    14. XM_017318450.3XP_017173939.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      UniProtKB/TrEMBL
      A0AAQ4VMU2, Q3UT06, Q3UUZ1, Q3UZA6
      Related
      ENSMUSP00000159995.1, ENSMUST00000249898.1
      Conserved Domains (2) summary
      cd12228
      Location:161244
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02169
      Location:445564
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    15. XM_036161896.1XP_036017789.1  ecto-NOX disulfide-thiol exchanger 2 isoform X20

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    16. XM_036161895.1XP_036017788.1  ecto-NOX disulfide-thiol exchanger 2 isoform X19

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    17. XM_036161894.1XP_036017787.1  ecto-NOX disulfide-thiol exchanger 2 isoform X18

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    18. XM_030251286.1XP_030107146.1  ecto-NOX disulfide-thiol exchanger 2 isoform X10

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (2) summary
      cd12228
      Location:161244
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02169
      Location:445564
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    19. XM_036161889.1XP_036017782.1  ecto-NOX disulfide-thiol exchanger 2 isoform X15

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:113196
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    20. XM_011250997.4XP_011249299.1  ecto-NOX disulfide-thiol exchanger 2 isoform X9

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:164247
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    21. XM_006541474.5XP_006541537.1  ecto-NOX disulfide-thiol exchanger 2 isoform X11

      UniProtKB/TrEMBL
      Q3UT06, Q3UUZ1, Q3UZA6
      Conserved Domains (1) summary
      cd12228
      Location:161244
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    22. XM_011250998.4XP_011249300.1  ecto-NOX disulfide-thiol exchanger 2 isoform X12

      UniProtKB/TrEMBL
      Q3UUZ1
      Conserved Domains (2) summary
      cd12228
      Location:164247
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02169
      Location:448567
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type