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    Cstdc2 cystatin domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 77705, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cstdc2provided by MGI
    Official Full Name
    cystatin domain containing 2provided by MGI
    Primary source
    MGI:MGI:1924955
    See related
    Ensembl:ENSMUSG00000027446 AllianceGenome:MGI:1924955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mCST E2; 9230104L09Rik
    Summary
    Predicted to be involved in antimicrobial humoral response. Predicted to be active in extracellular space. Is expressed in epididymis and testis. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 263.3) See more
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    Genomic context

    See Cstdc2 in Genome Data Viewer
    Location:
    2 G3; 2 73.58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (148686540..148692882, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (148844620..148850962, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05978 Neighboring gene cystatin 13 Neighboring gene cystatin 9 Neighboring gene STARR-seq mESC enhancer starr_05979 Neighboring gene cystatin C Neighboring gene STARR-seq mESC enhancer starr_05982 Neighboring gene predicted gene, 54123

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

    Markers

    Clone Names

    • MGC129250, MGC129251

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in antimicrobial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cystatin E2
    Names
    Cystatin 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029960.3NP_084236.1  cystatin E2 precursor

      See identical proteins and their annotated locations for NP_084236.1

      Status: VALIDATED

      Source sequence(s)
      AK020314, BB073321
      Consensus CDS
      CCDS16851.1
      UniProtKB/TrEMBL
      Q3SXH5, Q9D264
      Related
      ENSMUSP00000028937.3, ENSMUST00000028937.3
      Conserved Domains (1) summary
      cl09238
      Location:39113
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      148686540..148692882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239843.3XP_011238145.1  cystatin E2 isoform X1

      UniProtKB/TrEMBL
      Q3SXH5
      Conserved Domains (1) summary
      cl09238
      Location:39100
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.