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    Rae1 ribonucleic acid export 1 [ Mus musculus (house mouse) ]

    Gene ID: 66679, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rae1provided by MGI
    Official Full Name
    ribonucleic acid export 1provided by MGI
    Primary source
    MGI:MGI:1913929
    See related
    Ensembl:ENSMUSG00000027509 AllianceGenome:MGI:1913929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MNRP; MNRP41; D2Ertd342e; 3230401I12Rik
    Summary
    Predicted to enable RNA binding activity and ubiquitin binding activity. Acts upstream of or within cellular response to organic cyclic compound. Predicted to be located in mitotic spindle pole and nucleus. Predicted to be part of nuclear pore. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human RAE1 (ribonucleic acid export 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 61.6), ovary adult (RPKM 34.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rae1 in Genome Data Viewer
    Location:
    2 H3; 2 95.66 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172841909..172857532)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173000116..173015739)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 7 Neighboring gene enhancer in intron 1 of Bmp7 Neighboring gene predicted gene, 40010 Neighboring gene STARR-positive B cell enhancer ABC_E4526 Neighboring gene predicted gene, 52538 Neighboring gene SPO11 initiator of meiotic double stranded breaks Neighboring gene STARR-positive B cell enhancer ABC_E6029 Neighboring gene STARR-seq mESC enhancer starr_06607 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172852363-172852564 Neighboring gene VISTA enhancer mm92 Neighboring gene RNA binding motif protein 38 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172872098-172872385 Neighboring gene predicted gene, 36337

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mRNA export factor
    Names
    RAE1 RNA export 1 homolog
    mRNA-associated protein mrnp 41
    rae1 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175112.5NP_780321.1  mRNA export factor

      See identical proteins and their annotated locations for NP_780321.1

      Status: VALIDATED

      Source sequence(s)
      AL928599, BC059051, CO041965
      Consensus CDS
      CCDS17138.1
      UniProtKB/Swiss-Prot
      Q3UKD4, Q8C570
      UniProtKB/TrEMBL
      Q8CBU3
      Related
      ENSMUSP00000029013.4, ENSMUST00000029013.10
      Conserved Domains (2) summary
      sd00039
      Location:4284
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:40335
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      172841909..172857532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500024.5XP_006500087.1  mRNA export factor isoform X1

      See identical proteins and their annotated locations for XP_006500087.1

      UniProtKB/Swiss-Prot
      Q3UKD4, Q8C570
      UniProtKB/TrEMBL
      Q8CBU3
      Conserved Domains (2) summary
      sd00039
      Location:4284
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:40335
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006500023.2XP_006500086.1  mRNA export factor isoform X1

      See identical proteins and their annotated locations for XP_006500086.1

      UniProtKB/Swiss-Prot
      Q3UKD4, Q8C570
      UniProtKB/TrEMBL
      Q8CBU3
      Conserved Domains (2) summary
      sd00039
      Location:4284
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:40335
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...