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    Pmepa1 prostate transmembrane protein, androgen induced 1 [ Mus musculus (house mouse) ]

    Gene ID: 65112, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pmepa1provided by MGI
    Official Full Name
    prostate transmembrane protein, androgen induced 1provided by MGI
    Primary source
    MGI:MGI:1929600
    See related
    Ensembl:ENSMUSG00000038400 AllianceGenome:MGI:1929600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stag1; Erg1.2; N4wbp4; Tmepai; 2210418I02Rik
    Summary
    Predicted to enable R-SMAD binding activity and WW domain binding activity. Involved in negative regulation of SMAD protein signal transduction and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in endosome membrane. Predicted to be active in Golgi membrane and early endosome membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Orthologous to human PMEPA1 (prostate transmembrane protein, androgen induced 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 17.4), ovary adult (RPKM 16.8) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pmepa1 in Genome Data Viewer
    Location:
    2 H3; 2 95.85 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173066251..173118329, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173224458..173276731, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9076 Neighboring gene phosphoenolpyruvate carboxykinase 1, cytosolic Neighboring gene Z-DNA binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_06613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:173055154-173055337 Neighboring gene STARR-seq mESC enhancer starr_06615 Neighboring gene prostate transmembrane protein, androgen induced 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_06620 Neighboring gene predicted gene, 46780

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables R-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables R-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein TMEPAI
    Names
    NEDD4 WW domain-binding protein 4
    Nedd4 WW binding protein 4
    transmembrane prostate androgen-induced protein
    transmembrane, prostate androgen induced RNA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413585.1NP_001400514.1  protein TMEPAI isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL837509
    2. NM_001413590.1NP_001400519.1  protein TMEPAI isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL837509, AL837520
      UniProtKB/TrEMBL
      A2APF5
      Related
      ENSMUSP00000115534.3, ENSMUST00000139306.3
    3. NM_022995.4NP_075371.2  protein TMEPAI isoform 2

      See identical proteins and their annotated locations for NP_075371.2

      Status: VALIDATED

      Source sequence(s)
      AL837509, AL837520
      Consensus CDS
      CCDS38350.1
      UniProtKB/TrEMBL
      A2APF4, Q4QRN6
      Related
      ENSMUSP00000039950.7, ENSMUST00000036248.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      173066251..173118329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)