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    Fgl2 fibrinogen-like protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 14190, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fgl2provided by MGI
    Official Full Name
    fibrinogen-like protein 2provided by MGI
    Primary source
    MGI:MGI:103266
    See related
    Ensembl:ENSMUSG00000039899 AllianceGenome:MGI:103266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    musfiblp
    Summary
    Acts upstream of or within several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; negative regulation of antigen processing and presentation; and negative regulation of memory T cell differentiation. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including endometrium epithelium; extraembryonic component; nervous system; placenta; and skeleton. Used to study autoimmune glomerulonephritis. Orthologous to human FGL2 (fibrinogen like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 35.5), ovary adult (RPKM 23.3) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Fgl2 in Genome Data Viewer
    Location:
    5 A3; 5 9.83 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21577671..21583384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21372673..21378386)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42222 Neighboring gene gamma-secretase activating protein Neighboring gene STARR-seq mESC enhancer starr_12563 Neighboring gene STARR-positive B cell enhancer ABC_E6308 Neighboring gene coiled-coil domain containing 146 Neighboring gene VISTA enhancer mm186 Neighboring gene STARR-positive B cell enhancer ABC_E6309 Neighboring gene predicted gene, 50626 Neighboring gene STARR-positive B cell enhancer ABC_E6310 Neighboring gene STARR-seq mESC enhancer starr_12565 Neighboring gene STARR-positive B cell enhancer ABC_E3562 Neighboring gene STARR-positive B cell enhancer ABC_E152 Neighboring gene family with sequence similarity 185, member A Neighboring gene F-box and leucine-rich repeat protein 13 Neighboring gene STARR-seq mESC enhancer starr_12566 Neighboring gene STARR-seq mESC enhancer starr_12567 Neighboring gene leucine rich repeat containing 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    General protein information

    Preferred Names
    fibroleukin
    Names
    associated with MHV-3 induced prothrombinase activity
    cytotoxic T-lymphocyte-specific protein
    prothrombinase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008013.4NP_032039.2  fibroleukin precursor

      See identical proteins and their annotated locations for NP_032039.2

      Status: VALIDATED

      Source sequence(s)
      AK009500, AK036402, AK036784, BB016276, CB599038, W13307
      Consensus CDS
      CCDS19103.1
      UniProtKB/Swiss-Prot
      P12804
      UniProtKB/TrEMBL
      Q544K3
      Related
      ENSMUSP00000046131.6, ENSMUST00000035799.6
      Conserved Domains (2) summary
      pfam00147
      Location:202428
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam15456
      Location:72151
      Uds1; Up-regulated During Septation

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      21577671..21583384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)