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    Rab5b RAB5B, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19344, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rab5bprovided by MGI
    Official Full Name
    RAB5B, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:105938
    See related
    Ensembl:ENSMUSG00000000711 AllianceGenome:MGI:105938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C030027M18Rik
    Summary
    Predicted to enable GDP binding activity; GTP-dependent protein binding activity; and GTPase activity. Acts upstream of or within endosome organization and regulation of endocytosis. Located in endocytic vesicle. Is expressed in central nervous system; primary oocyte; and retina. Orthologous to human RAB5B (RAB5B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 40.7), kidney adult (RPKM 39.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rab5b in Genome Data Viewer
    Location:
    10 D3; 10 77.13 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128511980..128532160, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128677170..128696284, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene IKAROS family zinc finger 4 Neighboring gene predicted gene, 51824 Neighboring gene STARR-positive B cell enhancer ABC_E2343 Neighboring gene sulfite oxidase Neighboring gene ribosomal protein L12 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E50 Neighboring gene STARR-positive B cell enhancer ABC_E2974 Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2 Neighboring gene diacylglycerol kinase, alpha Neighboring gene STARR-positive B cell enhancer ABC_E5201 Neighboring gene STARR-seq mESC enhancer starr_28299 Neighboring gene STARR-positive B cell enhancer ABC_E10661 Neighboring gene predicted gene, 31504 Neighboring gene PYM homolog 1, exon junction complex associated factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC169198, MGC169199

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within endosome organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane to endosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane to endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-5B
    NP_803130.1
    XP_006513447.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428778.1NP_001415707.1  ras-related protein Rab-5B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC117232
      UniProtKB/Swiss-Prot
      P61021
      UniProtKB/TrEMBL
      B2RPS1
    2. NM_001428780.1NP_001415709.1  ras-related protein Rab-5B isoform b

      Status: VALIDATED

      Source sequence(s)
      AC117232
      UniProtKB/TrEMBL
      Q8C458
    3. NM_177411.5NP_803130.1  ras-related protein Rab-5B isoform a

      See identical proteins and their annotated locations for NP_803130.1

      Status: VALIDATED

      Source sequence(s)
      AC117232
      Consensus CDS
      CCDS24287.1
      UniProtKB/Swiss-Prot
      P61021
      UniProtKB/TrEMBL
      B2RPS1, Q0PD56
      Related
      ENSMUSP00000000727.3, ENSMUST00000000727.4
      Conserved Domains (1) summary
      cd01860
      Location:20182
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128511980..128532160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513384.5XP_006513447.1  ras-related protein Rab-5B isoform X1

      Conserved Domains (1) summary
      cd01860
      Location:20182
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011229.1: Suppressed sequence

      Description
      NM_011229.1: This RefSeq was permanently suppressed because it is redundant with NM_177411.3.