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    Nts neurotensin [ Mus musculus (house mouse) ]

    Gene ID: 67405, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ntsprovided by MGI
    Official Full Name
    neurotensinprovided by MGI
    Primary source
    MGI:MGI:1328351
    See related
    Ensembl:ENSMUSG00000019890 AllianceGenome:MGI:1328351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NN; NT; NT/N; NTS1; NMN-125; 5033428E16Rik
    Summary
    Predicted to enable neuropeptide receptor binding activity and receptor ligand activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; neuropeptide signaling pathway; and visual learning. Predicted to be located in intracellular membrane-bounded organelle and neuronal cell body. Predicted to be active in axon terminus. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; jaw; and retina. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human NTS (neurotensin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 17.8), large intestine adult (RPKM 7.5) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Nts in Genome Data Viewer
    Location:
    10 D1; 10 53.56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (102317617..102326294, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (102481756..102490418, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27741 Neighboring gene predicted gene, 26278 Neighboring gene MGAT4 family, member C Neighboring gene microRNA 3059 Neighboring gene STARR-seq mESC enhancer starr_27742 Neighboring gene STARR-seq mESC enhancer starr_27743 Neighboring gene STARR-seq mESC enhancer starr_27744 Neighboring gene STARR-seq mESC enhancer starr_27745 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 Neighboring gene predicted gene 5175

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neuropeptide hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables neuropeptide receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neurotensin/neuromedin N
    Names
    neuromedin N

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429471.1NP_001416400.1  neurotensin/neuromedin N isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131720
    2. NM_024435.3NP_077755.1  neurotensin/neuromedin N isoform 1 precursor

      See identical proteins and their annotated locations for NP_077755.1

      Status: VALIDATED

      Source sequence(s)
      AC131720
      Consensus CDS
      CCDS24154.1
      UniProtKB/Swiss-Prot
      Q9D3P9
      Related
      ENSMUSP00000020040.4, ENSMUST00000020040.5
      Conserved Domains (1) summary
      pfam07421
      Location:6168
      Pro-NT_NN; Neurotensin/neuromedin N precursor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      102317617..102326294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513992.4XP_006514055.1  neurotensin/neuromedin N isoform X1

      Conserved Domains (1) summary
      pfam07421
      Location:1129
      Pro-NT_NN; Neurotensin/neuromedin N precursor