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    Zfp277 zinc finger protein 277 [ Mus musculus (house mouse) ]

    Gene ID: 246196, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfp277provided by MGI
    Official Full Name
    zinc finger protein 277provided by MGI
    Primary source
    MGI:MGI:1890393
    See related
    Ensembl:ENSMUSG00000055917 AllianceGenome:MGI:1890393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NIRF4; Znf277; 2410017E24Rik
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to hydrogen peroxide and regulation of cellular senescence. Predicted to be located in chromosome; cytoplasm; and nucleolus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF277 (zinc finger protein 277). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.2), CNS E18 (RPKM 5.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zfp277 in Genome Data Viewer
    Location:
    12 B1; 12 18.06 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40365045..40495789, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40315046..40445790, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:40949998-40950107 Neighboring gene STARR-seq mESC enhancer starr_31954 Neighboring gene STARR-positive B cell enhancer mm9_chr12:40983751-40984051 Neighboring gene STARR-seq mESC enhancer starr_31955 Neighboring gene predicted gene 7008 Neighboring gene predicted gene, 40403 Neighboring gene STARR-seq mESC enhancer starr_31956 Neighboring gene STARR-seq mESC enhancer starr_31957 Neighboring gene STARR-seq mESC enhancer starr_31958 Neighboring gene STARR-positive B cell enhancer mm9_chr12:41172293-41172594 Neighboring gene predicted gene, 40406 Neighboring gene STARR-seq mESC enhancer starr_31959 Neighboring gene STARR-seq mESC enhancer starr_31960 Neighboring gene dedicator of cytokinesis 4 Neighboring gene STARR-seq mESC enhancer starr_31961 Neighboring gene STARR-seq mESC enhancer starr_31962 Neighboring gene STARR-seq mESC enhancer starr_31963 Neighboring gene STARR-seq mESC enhancer starr_31965 Neighboring gene STARR-seq mESC enhancer starr_31966 Neighboring gene predicted gene, 19441

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172575.3NP_766163.2  zinc finger protein 277 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123855, AK077401, BY206876
      Consensus CDS
      CCDS36435.1
      UniProtKB/Swiss-Prot
      E9Q6D6, Q3U0V6, Q3UM86, Q80UK2, Q8BVL5, Q8BVX7
      Related
      ENSMUSP00000064226.9, ENSMUST00000069692.10
      Conserved Domains (2) summary
      sd00020
      Location:353375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12756
      Location:302389
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    2. NM_178845.3NP_849173.2  zinc finger protein 277 isoform 2

      See identical proteins and their annotated locations for NP_849173.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC123855, AK075945, BY206876
      Consensus CDS
      CCDS25894.1
      UniProtKB/TrEMBL
      Q3U0V6, Q8BVX7
      Related
      ENSMUSP00000068032.8, ENSMUST00000069637.15
      Conserved Domains (2) summary
      sd00020
      Location:227249
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12756
      Location:176263
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      40365045..40495789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)