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    Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit methionine [ Mus musculus (house mouse) ]

    Gene ID: 108645, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mat2bprovided by MGI
    Official Full Name
    methionine adenosyltransferase 2 non-catalytic beta subunit methionineprovided by MGI
    Primary source
    MGI:MGI:1913667
    See related
    Ensembl:ENSMUSG00000042032 AllianceGenome:MGI:1913667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TGR; MAT-II; MATIIbeta; 1110064C04Rik; 2410018D16Rik
    Summary
    Predicted to enable enzyme binding activity and methionine adenosyltransferase regulator activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAT2B (methionine adenosyltransferase 2 non-catalytic beta subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 34.1), bladder adult (RPKM 28.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mat2b in Genome Data Viewer
    Location:
    11 A5; 11 24.4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (40570141..40586030, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (40679314..40695203, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29228 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6966 Neighboring gene hyaluronan mediated motility receptor (RHAMM) Neighboring gene STARR-seq mESC enhancer starr_29231 Neighboring gene STARR-seq mESC enhancer starr_29232 Neighboring gene NudC domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methionine adenosyltransferase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methionine adenosyltransferase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables methionine adenosyltransferase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in S-adenosylmethionine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in S-adenosylmethionine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of methionine adenosyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of methionine adenosyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of methionine adenosyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    methionine adenosyltransferase 2 subunit beta
    Names
    MAT II beta
    methionine adenosyltransferase 2 beta subunit
    methionine adenosyltransferase II, beta
    NP_001186203.1
    NP_598778.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199274.1NP_001186203.1  methionine adenosyltransferase 2 subunit beta isoform 2

      See identical proteins and their annotated locations for NP_001186203.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate first exon which includes different sequence for the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct and shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK075947, BC003457, CA559663
      Consensus CDS
      CCDS56767.1
      UniProtKB/Swiss-Prot
      Q99LB6
      Related
      ENSMUSP00000098901.4, ENSMUST00000101347.10
      Conserved Domains (2) summary
      cd05254
      Location:19305
      dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
      pfam04321
      Location:20311
      RmlD_sub_bind; RmlD substrate binding domain
    2. NM_134017.2NP_598778.1  methionine adenosyltransferase 2 subunit beta isoform 1

      See identical proteins and their annotated locations for NP_598778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform a).
      Source sequence(s)
      AL646055, BC003457
      Consensus CDS
      CCDS24547.1
      UniProtKB/Swiss-Prot
      Q5NC89, Q76LX2, Q8BVX6, Q8BYT9, Q99LB6
      Related
      ENSMUSP00000048222.5, ENSMUST00000040167.11
      Conserved Domains (2) summary
      cd05254
      Location:30316
      dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
      pfam04321
      Location:31322
      RmlD_sub_bind; RmlD substrate binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      40570141..40586030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)