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    Gabpa GA repeat binding protein, alpha [ Mus musculus (house mouse) ]

    Gene ID: 14390, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gabpaprovided by MGI
    Official Full Name
    GA repeat binding protein, alphaprovided by MGI
    Primary source
    MGI:MGI:95610
    See related
    Ensembl:ENSMUSG00000008976 AllianceGenome:MGI:95610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GABPalpha
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within blastocyst formation; negative regulation of megakaryocyte differentiation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human GABPA (GA binding protein transcription factor subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.4), limb E14.5 (RPKM 10.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gabpa in Genome Data Viewer
    Location:
    16 C3.3; 16 46.92 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (84631795..84660671)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (84834891..84863783)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41365 Neighboring gene predicted gene, 32202 Neighboring gene STARR-seq mESC enhancer starr_41367 Neighboring gene junction adhesion molecule 2 Neighboring gene STARR-positive B cell enhancer ABC_E5555 Neighboring gene predicted gene, 46557 Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene STARR-seq mESC enhancer starr_41374 Neighboring gene STARR-seq mESC enhancer starr_41375 Neighboring gene predicted gene 10791 Neighboring gene amyloid beta precursor protein Neighboring gene predicted gene, 49227

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    GA-binding protein alpha chain
    Names
    GA-binding protein alpha-subunit
    GABP subunit alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416806.1NP_001403735.1  GA-binding protein alpha chain isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      Q00422, Q7TT22
      UniProtKB/TrEMBL
      Q6HAA1
    2. NM_001416807.1NP_001403736.1  GA-binding protein alpha chain isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/Swiss-Prot
      Q00422, Q7TT22
      UniProtKB/TrEMBL
      Q6HAA1
      Related
      ENSMUSP00000109822.2, ENSMUST00000114184.8
    3. NM_001416809.1NP_001403738.1  GA-binding protein alpha chain isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/TrEMBL
      Q6HAA1
    4. NM_001416810.1NP_001403739.1  GA-binding protein alpha chain isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/TrEMBL
      Q6HAA1
    5. NM_001416811.1NP_001403740.1  GA-binding protein alpha chain isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/TrEMBL
      Q6HAA1
    6. NM_001416812.1NP_001403741.1  GA-binding protein alpha chain isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/TrEMBL
      Q6HAA1
    7. NM_001416813.1NP_001403742.1  GA-binding protein alpha chain isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC164162
      UniProtKB/TrEMBL
      Q6HAA1
    8. NM_008065.3NP_032091.2  GA-binding protein alpha chain isoform 1

      See identical proteins and their annotated locations for NP_032091.2

      Status: VALIDATED

      Source sequence(s)
      AC164162
      Consensus CDS
      CCDS28284.1
      UniProtKB/Swiss-Prot
      Q00422, Q7TT22
      UniProtKB/TrEMBL
      Q6HAA1
      Related
      ENSMUSP00000009120.8, ENSMUST00000009120.8
      Conserved Domains (3) summary
      cd08534
      Location:168254
      SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
      smart00413
      Location:319403
      ETS; erythroblast transformation specific domain
      pfam11620
      Location:40119
      GABP-alpha; GA-binding protein alpha chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      84631795..84660671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522906.3XP_006522969.1  GA-binding protein alpha chain isoform X1

      See identical proteins and their annotated locations for XP_006522969.1

      UniProtKB/TrEMBL
      Q6HAA1
      Conserved Domains (3) summary
      cd08534
      Location:168254
      SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
      smart00413
      Location:321405
      ETS; erythroblast transformation specific domain
      pfam11620
      Location:40119
      GABP-alpha; GA-binding protein alpha chain
    2. XM_006522905.5XP_006522968.1  GA-binding protein alpha chain isoform X1

      See identical proteins and their annotated locations for XP_006522968.1

      UniProtKB/TrEMBL
      Q6HAA1
      Conserved Domains (3) summary
      cd08534
      Location:168254
      SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
      smart00413
      Location:321405
      ETS; erythroblast transformation specific domain
      pfam11620
      Location:40119
      GABP-alpha; GA-binding protein alpha chain
    3. XM_017316875.3XP_017172364.1  GA-binding protein alpha chain isoform X3

      UniProtKB/TrEMBL
      Q6HAA1
      Conserved Domains (3) summary
      smart00413
      Location:256340
      ETS; erythroblast transformation specific domain
      pfam11620
      Location:40119
      GABP-alpha; GA-binding protein alpha chain
      cl15755
      Location:168192
      SAM_superfamily; SAM (Sterile alpha motif )

    RNA

    1. XR_876129.4 RNA Sequence