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    Tiparp TCDD-inducible poly(ADP-ribose) polymerase [ Mus musculus (house mouse) ]

    Gene ID: 99929, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tiparpprovided by MGI
    Official Full Name
    TCDD-inducible poly(ADP-ribose) polymeraseprovided by MGI
    Primary source
    MGI:MGI:2159210
    See related
    Ensembl:ENSMUSG00000034640 AllianceGenome:MGI:2159210
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PARP7; ARTD14
    Summary
    Enables NAD+-protein poly-ADP-ribosyltransferase activity. Acts upstream of or within several processes, including androgen metabolic process; face morphogenesis; and vasculogenesis. Predicted to be active in nucleus. Is expressed in bladder; reproductive system; telencephalon; and tongue. Orthologous to human TIPARP (TCDD inducible poly(ADP-ribose) polymerase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 8.4), genital fat pad adult (RPKM 4.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tiparp in Genome Data Viewer
    Location:
    3 E1; 3 30.2 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (65435868..65462939)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (65528447..65555518)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40066 Neighboring gene predicted gene, 38503 Neighboring gene STARR-positive B cell enhancer ABC_E3434 Neighboring gene STARR-positive B cell enhancers ABC_E3435 and mm9_chr3:65320566-65320867 Neighboring gene RIKEN cDNA 4931440P22 gene Neighboring gene STARR-positive B cell enhancer ABC_E1620 Neighboring gene predicted gene, 22279 Neighboring gene predicted gene, 34924 Neighboring gene STARR-positive B cell enhancer ABC_E11188 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+-protein ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables NAD+-protein-aspartate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-protein-cysteine ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+-protein-cysteine ADP-ribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within androgen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within estrogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within excretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to 2,3,7,8-tetrachlorodibenzodioxine IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein mono-ADP-ribosyltransferase TIPARP
    Names
    ADP-ribosyltransferase diphtheria toxin-like 14
    NP_849223.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178892.5NP_849223.2  protein mono-ADP-ribosyltransferase TIPARP

      See identical proteins and their annotated locations for NP_849223.2

      Status: PROVISIONAL

      Source sequence(s)
      AC113279
      Consensus CDS
      CCDS17388.1
      UniProtKB/Swiss-Prot
      Q3UD50, Q8C032, Q8C1B2
      Related
      ENSMUSP00000048051.4, ENSMUST00000047906.10
      Conserved Domains (2) summary
      cd01439
      Location:529648
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam02825
      Location:348401
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      65435868..65462939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)