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    Bin3 bridging integrator 3 [ Mus musculus (house mouse) ]

    Gene ID: 57784, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bin3provided by MGI
    Official Full Name
    bridging integrator 3provided by MGI
    Primary source
    MGI:MGI:1929883
    See related
    Ensembl:ENSMUSG00000022089 AllianceGenome:MGI:1929883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700015F07Rik
    Summary
    Predicted to contribute to lipid binding activity. Acts upstream of or within myoblast migration involved in skeletal muscle regeneration; regulation of lamellipodium assembly; and skeletal muscle fiber development. Located in actin cytoskeleton. Is expressed in several structures, including 1st branchial arch; lens; limb; and testis. Orthologous to human BIN3 (bridging integrator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 5.9), liver E14 (RPKM 5.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bin3 in Genome Data Viewer
    Location:
    14 D2; 14 36.21 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70337538..70375413)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70100089..70137964)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene predicted gene, 33524 Neighboring gene STARR-seq mESC enhancer starr_37072 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70468715-70469016 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70469146-70469446 Neighboring gene STARR-positive B cell enhancer ABC_E8569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70499772-70499955 Neighboring gene early growth response 3 Neighboring gene RIKEN cDNA 9930012K11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70553578-70553761 Neighboring gene cell cycle activator and apoptosis regulator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bin3 deletion causes cataracts and increased susceptibility to lymphoma during aging. Ramalingam A, et al. Cancer Res, 2008 Mar 15. PMID 18339847
    2. The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis. Simionescu-Bankston A, et al. Dev Biol, 2013 Oct 1. PMID 23872330, Free PMC Article
    3. Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. Routhier EL, et al. J Biol Chem, 2001 Jun 15. PMID 11274158
    4. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Xue W, et al. Proc Natl Acad Sci U S A, 2012 May 22. PMID 22566646, Free PMC Article
    5. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Choquet H, et al. Nat Commun, 2021 Jun 14. PMID 34127677, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cortical patch localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myoblast migration involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in unidimensional cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in unidimensional cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bridging integrator 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360404.1 → NP_001347333.1  bridging integrator 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151836, AI464318, AK005992, BB682940, CA562064, CX565660
      UniProtKB/TrEMBL
      Q3TC47
      Conserved Domains (1) summary
      cl12013
      Location:1 → 192
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_021328.4 → NP_067303.1  bridging integrator 3 isoform 1

      See identical proteins and their annotated locations for NP_067303.1

      Status: VALIDATED

      Source sequence(s)
      AC151836, AI464318, AK005992, BB682940, CA562064
      Consensus CDS
      CCDS27247.1
      UniProtKB/Swiss-Prot
      Q9JI08
      UniProtKB/TrEMBL
      Q3TC47
      Related
      ENSMUSP00000022680.8, ENSMUST00000022680.9
      Conserved Domains (1) summary
      cd07590
      Location:12 → 236
      BAR_Bin3; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70337538..70375413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519330.4 → XP_006519393.1  bridging integrator 3 isoform X1

      UniProtKB/TrEMBL
      Q3TC47
      Conserved Domains (1) summary
      cd07590
      Location:12 → 209
      BAR_Bin3; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3

    2. XM_030247901.1 → XP_030103761.1  bridging integrator 3 isoform X3

      Conserved Domains (1) summary
      cl12013
      Location:1 → 114
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_006519332.4 → XP_006519395.1  bridging integrator 3 isoform X2

      See identical proteins and their annotated locations for XP_006519395.1

      UniProtKB/TrEMBL
      Q3TC47
      Conserved Domains (1) summary
      cl12013
      Location:1 → 192
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_030247902.1 → XP_030103762.1  bridging integrator 3 isoform X3

      Conserved Domains (1) summary
      cl12013
      Location:1 → 114
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_036158770.1 → XP_036014663.1  bridging integrator 3 isoform X2

      UniProtKB/TrEMBL
      Q3TC47
      Conserved Domains (1) summary
      cl12013
      Location:1 → 192
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_036158771.1 → XP_036014664.1  bridging integrator 3 isoform X2

      UniProtKB/TrEMBL
      Q3TC47
      Conserved Domains (1) summary
      cl12013
      Location:1 → 192
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_011245124.2 → XP_011243426.1  bridging integrator 3 isoform X3

      Conserved Domains (1) summary
      cl12013
      Location:1 → 114
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JI08.1 GenPept UniProtKB/Swiss-Prot:Q9JI08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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