Arf1 ARF GTPase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arf1provided by MGI
Official Full Name: ARF GTPase 1provided by MGI
Primary source: MGI:MGI:99431
See related: Ensembl:ENSMUSG00000048076 AllianceGenome:MGI:99431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables GTP binding activity and magnesium ion binding activity. Involved in mitotic cleavage furrow ingression. Acts upstream of or within vesicle-mediated transport. Located in Golgi apparatus; cytosol; and sarcomere. Part of protein-containing complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 273.0), duodenum adult (RPKM 269.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 37.05 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (59102237..59119042, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (59211412..59228267, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arf1 GTPase Regulates Golgi-Dependent G2/M Transition and Spindle Organization in Oocyte Meiosis.
Title: Arf1 GTPase Regulates Golgi-Dependent G2/M Transition and Spindle Organization in Oocyte Meiosis.
Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development.
Title: Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development.
Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti-Tumor Immunity.
Title: Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti-Tumor Immunity.
ARF1 maintains intestinal homeostasis by modulating gut microbiota and stem cell function.
Title: ARF1 maintains intestinal homeostasis by modulating gut microbiota and stem cell function.
Kinetics of Arf1 inactivation regulates Golgi organisation and function in non-adherent fibroblasts.
Title: Kinetics of Arf1 inactivation regulates Golgi organisation and function in non-adherent fibroblasts.
Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation.
Title: Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation.
Arf1-pathway knockdown not only kills Cancer stem cells but also elicits a tumor-specific immune response that converts dying Cancer stem cells into a therapeutic vaccine, leading to durable benefits.
Title: Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice.
findings define a novel role of SHP2 in stabilizing junctional VE-cadherin in the resting endothelial barrier through suppressing MET and ARF1 activation
Title: SHP2 protects endothelial cell barrier through suppressing VE-cadherin internalization regulated by MET-ARF1.
results suggest that the peptide derived from ARF1 could be developed into a novel anti-allergic agent for therapeutic intervention in allergy and mast cell-related pathologies.
Title: Identification of the minimal region of peptide derived from ADP-ribosylation factor1 (ARF1) that inhibits IgE-mediated mast cell activation.
The authors found that Arf1 occupies contrasting molecular environments within the Coat Protein Complex I, leading them to hypothesize that some Arf1 molecules may regulate vesicle assembly while others regulate coat disassembly.
Title: 9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Arf1 (e-PCR), detects polymorphism
- UniSTS:259584

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables phospholipase D activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to transport vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine organization	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular copper ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular copper ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysosomal membrane organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic cleavage furrow ingression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ER to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of late endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	TAS Traceable Author Statement more info	PubMed
involved_in regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle budding	ISO Inferred from Sequence Orthology more info
involved_in very-low-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in COPI-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor 1

NP_001123880.1

EC 3.6.5.2

NP_031502.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.