Sipa1l1 signal-induced proliferation-associated 1 like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sipa1l1provided by MGI
Official Full Name: signal-induced proliferation-associated 1 like 1provided by MGI
Primary source: MGI:MGI:2443679
See related: Ensembl:ENSMUSG00000042700 AllianceGenome:MGI:2443679
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spar; mKIAA0440; 4931426N11Rik
Summary: Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway and regulation of axonogenesis. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SIPA1L1 (signal induced proliferation associated 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 37.5), cortex adult (RPKM 30.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D1; 12 38.14 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (82216138..82498560)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (82169377..82451786)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling.
Title: SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling.
PDZ domain-containing protein Sipa1l1 (signal-induced proliferation-associated 1 like 1) binds to the cytoplasmic PDZ-ligand motif of aquaporin-2 and accelerates its endocytosis in the absence of vasopressin
Title: Vasopressin-induced serine 269 phosphorylation reduces Sipa1l1 (signal-induced proliferation-associated 1 like 1)-mediated aquaporin-2 endocytosis.
Our data establish an integral feedback loop involving NF-kappaB, Plks, and SPAR that regulates the end point of homeostatic synaptic adaptation to elevated activity and implicate a transcription factor in the regulation of homeostatic synaptic responses.
Title: Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation.
SPAR is functionally required for synaptic plasticity and contributes to the IH-induced enhancement of spatial learning and memory in postnatal developing mice.
Title: Hippocampal spine-associated Rap-specific GTPase-activating protein induces enhancement of learning and memory in postnatally hypoxia-exposed mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in ephrin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal-induced proliferation-associated 1-like protein 1

Names: SIPA1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167983.1 → NP_001161455.1 signal-induced proliferation-associated 1-like protein 1 isoform 2

See identical proteins and their annotated locations for NP_001161455.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate coding exon compared to variant 1, resulting in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK078420, AK122284, BC058681, BP765364

Consensus CDS

CCDS49105.1

UniProtKB/Swiss-Prot

Q8C0T5

Related

ENSMUSP00000152356.2, ENSMUST00000222298.2

Conserved Domains (3) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1483 → 1727

SPAR_C; C-terminal domain of SPAR protein
NM_001407402.1 → NP_001394331.1 signal-induced proliferation-associated 1-like protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643
NM_001407403.1 → NP_001394332.1 signal-induced proliferation-associated 1-like protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643

UniProtKB/Swiss-Prot

Q6PDI8, Q80U02, Q8C026, Q8C0T5

Related

ENSMUSP00000131030.3, ENSMUST00000166429.9
NM_001407404.1 → NP_001394333.1 signal-induced proliferation-associated 1-like protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643

UniProtKB/Swiss-Prot

Q6PDI8, Q80U02, Q8C026, Q8C0T5
NM_001407405.1 → NP_001394334.1 signal-induced proliferation-associated 1-like protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643

UniProtKB/Swiss-Prot

Q6PDI8, Q80U02, Q8C026, Q8C0T5
NM_001407406.1 → NP_001394335.1 signal-induced proliferation-associated 1-like protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC122227, AC156643

UniProtKB/Swiss-Prot

Q6PDI8, Q80U02, Q8C026, Q8C0T5

Related

ENSMUSP00000061014.7, ENSMUST00000053969.7
NM_001407407.1 → NP_001394336.1 signal-induced proliferation-associated 1-like protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC122227, AC156643
NM_001407408.1 → NP_001394337.1 signal-induced proliferation-associated 1-like protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643
NM_001407409.1 → NP_001394338.1 signal-induced proliferation-associated 1-like protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643
NM_001407410.1 → NP_001394339.1 signal-induced proliferation-associated 1-like protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643
NM_001407411.1 → NP_001394340.1 signal-induced proliferation-associated 1-like protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643

UniProtKB/TrEMBL

Q4VBF8

Related

ENSMUSP00000152681.2, ENSMUST00000220963.2
NM_001407412.1 → NP_001394341.1 signal-induced proliferation-associated 1-like protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643

UniProtKB/TrEMBL

Q4VBF8
NM_001407413.1 → NP_001394342.1 signal-induced proliferation-associated 1-like protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643
NM_001407414.1 → NP_001394343.1 signal-induced proliferation-associated 1-like protein 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643
NM_001407415.1 → NP_001394344.1 signal-induced proliferation-associated 1-like protein 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643
NM_172579.4 → NP_766167.2 signal-induced proliferation-associated 1-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_766167.2

Status: VALIDATED

Source sequence(s)

AC122227, AC130222, AC156643

Consensus CDS

CCDS26026.1

UniProtKB/Swiss-Prot

Q6PDI8, Q80U02, Q8C026, Q8C0T5

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1715 → 1770

ZapB; Cell division protein ZapB

pfam11881
Location:1483 → 1727

SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

82216138..82498560

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244060.4 → XP_011242362.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011242362.1

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1729 → 1784

ZapB; Cell division protein ZapB

pfam11881
Location:1496 → 1741

SPAR_C; C-terminal domain of SPAR protein
XM_011244067.4 → XP_011242369.1 signal-induced proliferation-associated 1-like protein 1 isoform X2

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1728 → 1783

ZapB; Cell division protein ZapB

pfam11881
Location:1500 → 1740

SPAR_C; C-terminal domain of SPAR protein
XM_011244061.3 → XP_011242363.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011242363.1

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1729 → 1784

ZapB; Cell division protein ZapB

pfam11881
Location:1496 → 1741

SPAR_C; C-terminal domain of SPAR protein
XM_036157315.1 → XP_036013208.1 signal-induced proliferation-associated 1-like protein 1 isoform X3

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1716 → 1771

ZapB; Cell division protein ZapB

pfam11881
Location:1483 → 1728

SPAR_C; C-terminal domain of SPAR protein
XM_017315025.2 → XP_017170514.1 signal-induced proliferation-associated 1-like protein 1 isoform X4

UniProtKB/Swiss-Prot

Q6PDI8, Q80U02, Q8C026, Q8C0T5

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1715 → 1770

ZapB; Cell division protein ZapB

pfam11881
Location:1483 → 1727

SPAR_C; C-terminal domain of SPAR protein
XM_017315027.2 → XP_017170516.1 signal-induced proliferation-associated 1-like protein 1 isoform X5

Conserved Domains (4) summary

cd00992
Location:459 → 529

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:135 → 315

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1235 → 1290

ZapB; Cell division protein ZapB

pfam11881
Location:1006 → 1247

SPAR_C; C-terminal domain of SPAR protein
XM_017315026.2 → XP_017170515.1 signal-induced proliferation-associated 1-like protein 1 isoform X5

Conserved Domains (4) summary

cd00992
Location:459 → 529

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:135 → 315

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1235 → 1290

ZapB; Cell division protein ZapB

pfam11881
Location:1006 → 1247

SPAR_C; C-terminal domain of SPAR protein
XM_030246655.1 → XP_030102515.1 signal-induced proliferation-associated 1-like protein 1 isoform X5

Conserved Domains (4) summary

cd00992
Location:459 → 529

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:135 → 315

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1235 → 1290

ZapB; Cell division protein ZapB

pfam11881
Location:1006 → 1247

SPAR_C; C-terminal domain of SPAR protein
XM_030246653.2 → XP_030102513.1 signal-induced proliferation-associated 1-like protein 1 isoform X5

Conserved Domains (4) summary

cd00992
Location:459 → 529

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:135 → 315

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1235 → 1290

ZapB; Cell division protein ZapB

pfam11881
Location:1006 → 1247

SPAR_C; C-terminal domain of SPAR protein
XM_030246652.1 → XP_030102512.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1729 → 1784

ZapB; Cell division protein ZapB

pfam11881
Location:1496 → 1741

SPAR_C; C-terminal domain of SPAR protein
XM_030246656.1 → XP_030102516.1 signal-induced proliferation-associated 1-like protein 1 isoform X5

Conserved Domains (4) summary

cd00992
Location:459 → 529

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:135 → 315

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1235 → 1290

ZapB; Cell division protein ZapB

pfam11881
Location:1006 → 1247

SPAR_C; C-terminal domain of SPAR protein
XM_011244064.4 → XP_011242366.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011242366.1

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1729 → 1784

ZapB; Cell division protein ZapB

pfam11881
Location:1496 → 1741

SPAR_C; C-terminal domain of SPAR protein
XM_011244066.4 → XP_011242368.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011242368.1

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1729 → 1784

ZapB; Cell division protein ZapB

pfam11881
Location:1496 → 1741

SPAR_C; C-terminal domain of SPAR protein
XM_011244063.4 → XP_011242365.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011242365.1

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1729 → 1784

ZapB; Cell division protein ZapB

pfam11881
Location:1496 → 1741

SPAR_C; C-terminal domain of SPAR protein
XM_030246654.2 → XP_030102514.1 signal-induced proliferation-associated 1-like protein 1 isoform X5

Conserved Domains (4) summary

cd00992
Location:459 → 529

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:135 → 315

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1235 → 1290

ZapB; Cell division protein ZapB

pfam11881
Location:1006 → 1247

SPAR_C; C-terminal domain of SPAR protein
XM_030246657.2 → XP_030102517.1 signal-induced proliferation-associated 1-like protein 1 isoform X5

Conserved Domains (4) summary

cd00992
Location:459 → 529

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:135 → 315

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1235 → 1290

ZapB; Cell division protein ZapB

pfam11881
Location:1006 → 1247

SPAR_C; C-terminal domain of SPAR protein
XM_036157314.1 → XP_036013207.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1729 → 1784

ZapB; Cell division protein ZapB

pfam11881
Location:1496 → 1741

SPAR_C; C-terminal domain of SPAR protein
XM_011244062.2 → XP_011242364.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011242364.1

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1729 → 1784

ZapB; Cell division protein ZapB

pfam11881
Location:1496 → 1741

SPAR_C; C-terminal domain of SPAR protein
XM_006515684.3 → XP_006515747.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006515747.1

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1729 → 1784

ZapB; Cell division protein ZapB

pfam11881
Location:1496 → 1741

SPAR_C; C-terminal domain of SPAR protein
XM_017315029.1 → XP_017170518.1 signal-induced proliferation-associated 1-like protein 1 isoform X6

Conserved Domains (4) summary

cd00992
Location:428 → 498

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:104 → 284

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1204 → 1259

ZapB; Cell division protein ZapB

pfam11881
Location:975 → 1216

SPAR_C; C-terminal domain of SPAR protein