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    Rskr ribosomal protein S6 kinase related [ Mus musculus (house mouse) ]

    Gene ID: 216976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rskrprovided by MGI
    Official Full Name
    ribosomal protein S6 kinase relatedprovided by MGI
    Primary source
    MGI:MGI:2652869
    See related
    Ensembl:ENSMUSG00000037593 AllianceGenome:MGI:2652869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sgk494
    Summary
    Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Orthologous to human RSKR (ribosomal protein S6 kinase related). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 4.5), testis adult (RPKM 2.6) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rskr in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78181580..78187631)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78290712..78296805)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30092 Neighboring gene stromal cell derived factor 2 Neighboring gene small nuclear ribonucleoprotein N pseudogene Neighboring gene bridge-like lipid transfer protein family member 2 Neighboring gene predicted gene 3948 Neighboring gene STARR-positive B cell enhancer ABC_E9832 Neighboring gene sperm associated antigen 5 Neighboring gene aldolase C, fructose-bisphosphate

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase-related protein
    Names
    sugen kinase 494
    NP_001274135.1
    NP_001391729.1
    NP_001391743.1
    NP_001391746.1
    NP_001391749.1
    NP_001391750.1
    NP_001391751.1
    NP_001391752.1
    NP_001391753.1
    NP_001391754.1
    NP_001391755.1
    XP_006533032.1
    XP_006533033.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287206.1 → NP_001274135.1  ribosomal protein S6 kinase-related protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591070, BC059191, BY266382
      Conserved Domains (1) summary
      cl21453
      Location:108 → 352
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001404800.1 → NP_001391729.1  ribosomal protein S6 kinase-related protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591070
      UniProtKB/TrEMBL
      A0A5F8MPD4
      Related
      ENSMUSP00000158919.2, ENSMUST00000238934.2

    3. NM_001404814.1 → NP_001391743.1  ribosomal protein S6 kinase-related protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL591070

    4. NM_001404817.1 → NP_001391746.1  ribosomal protein S6 kinase-related protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591070

    5. NM_001404820.1 → NP_001391749.1  ribosomal protein S6 kinase-related protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL591070

    6. NM_001404821.1 → NP_001391750.1  ribosomal protein S6 kinase-related protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL591070

    7. NM_001404822.1 → NP_001391751.1  ribosomal protein S6 kinase-related protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL591070

    8. NM_001404823.1 → NP_001391752.1  ribosomal protein S6 kinase-related protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL591070

    9. NM_001404824.1 → NP_001391753.1  ribosomal protein S6 kinase-related protein isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL591070

    10. NM_001404825.1 → NP_001391754.1  ribosomal protein S6 kinase-related protein isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL591070

    11. NM_001404826.1 → NP_001391755.1  ribosomal protein S6 kinase-related protein isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL591070

    RNA

    1. NR_175867.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591070

    2. NR_175868.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591070

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78181580..78187631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532969.5 → XP_006533032.1  ribosomal protein S6 kinase-related protein isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:20 → 219
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006532970.5 → XP_006533033.1  ribosomal protein S6 kinase-related protein isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:2 → 171
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_388408.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001045522.1: Suppressed sequence

      Description
      NM_001045522.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SYL1.1 GenPept UniProtKB/Swiss-Prot:Q5SYL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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