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    Nrarp Notch-regulated ankyrin repeat protein [ Mus musculus (house mouse) ]

    Gene ID: 67122, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nrarpprovided by MGI
    Official Full Name
    Notch-regulated ankyrin repeat proteinprovided by MGI
    Primary source
    MGI:MGI:1914372
    See related
    Ensembl:ENSMUSG00000078202 AllianceGenome:MGI:1914372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700054M22Rik
    Summary
    Acts upstream of or within several processes, including angiogenesis; positive regulation of vascular endothelial cell proliferation; and somite rostral/caudal axis specification. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; genitourinary system; and retina. Orthologous to human NRARP (NOTCH regulated ankyrin repeat protein). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See Nrarp in Genome Data Viewer
    Location:
    2 A3; 2 17.05 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25070770..25073351)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25180758..25183339)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 8 Neighboring gene NADPH oxidase activator 1 Neighboring gene STARR-seq mESC enhancer starr_03957 Neighboring gene VISTA enhancer mm1454 Neighboring gene predicted gene 13387 Neighboring gene predicted gene, 52547 Neighboring gene STARR-positive B cell enhancer ABC_E3362 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25052129-25052238 Neighboring gene torsin family 4, member A

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloroplast targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in branching involved in blood vessel morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of vascular endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to chloroplast IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within somite rostral/caudal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of vascular endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vascular endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    notch-regulated ankyrin repeat-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025980.2NP_080256.2  notch-regulated ankyrin repeat-containing protein

      See identical proteins and their annotated locations for NP_080256.2

      Status: VALIDATED

      Source sequence(s)
      AY046077
      Consensus CDS
      CCDS38066.1
      UniProtKB/Swiss-Prot
      Q80UV7, Q91ZA8, Q9CZM1
      Related
      ENSMUSP00000100615.3, ENSMUST00000104999.4
      Conserved Domains (2) summary
      sd00045
      Location:5081
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:21106
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25070770..25073351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)