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    Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 14127, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fcer1gprovided by MGI
    Official Full Name
    Fc receptor, IgE, high affinity I, gamma polypeptideprovided by MGI
    Primary source
    MGI:MGI:95496
    See related
    Ensembl:ENSMUSG00000058715 AllianceGenome:MGI:95496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD23; Fce1g; Ly-50; FcR[g]; FcRgamma; FcR-gamma; FcepsilonRI
    Summary
    Enables IgE receptor activity; IgG binding activity; and identical protein binding activity. Contributes to IgE binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of interleukin-4 production; and serotonin secretion by platelet. Acts upstream of or within several processes, including immune response-regulating cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of immune effector process. Located in external side of plasma membrane. Part of Fc-epsilon receptor I complex. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina. Orthologous to human FCER1G (Fc epsilon receptor Ig). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 104.3), mammary gland adult (RPKM 62.3) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Fcer1g in Genome Data Viewer
    Location:
    1 H3; 1 79.23 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171057141..171061918, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171229572..171234349, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 1, group I, member 3 Neighboring gene translocase of outer mitochondrial membrane 40-like Neighboring gene STARR-positive B cell enhancer ABC_E1573 Neighboring gene apolipoprotein A-II Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene STARR-seq mESC enhancer starr_03024 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to IgE binding PubMed 
    enables IgE binding PubMed 
    contributes_to IgE binding PubMed 
    enables IgE receptor activity  
    enables IgE receptor activity PubMed 
    enables IgE receptor activity PubMed 
    enables IgG binding  
    enables IgG binding PubMed 
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    Items 1 - 25 of 69
    Process Evidence Code Pubs
    involved_in Fc receptor mediated stimulatory signaling pathway  
    acts_upstream_of_or_within Fc receptor mediated stimulatory signaling pathway PubMed 
    involved_in Fc-epsilon receptor signaling pathway  
    involved_in Fc-epsilon receptor signaling pathway  
    involved_in Fc-gamma receptor signaling pathway  
    acts_upstream_of_or_within Fc-gamma receptor signaling pathway PubMed 
    involved_in T cell differentiation involved in immune response  
    acts_upstream_of_or_within T cell differentiation involved in immune response PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway PubMed 
    involved_in cellular response to low-density lipoprotein particle stimulus PubMed 
    involved_in defense response to bacterium  
    acts_upstream_of_or_within defense response to bacterium PubMed 
    involved_in immunoglobulin mediated immune response  
    acts_upstream_of_or_within immunoglobulin mediated immune response PubMed 
    involved_in innate immune response  
    acts_upstream_of_or_within innate immune response PubMed 
    involved_in integrin-mediated signaling pathway PubMed 
    acts_upstream_of_or_within interleukin-2 production PubMed 
    involved_in interleukin-3-mediated signaling pathway PubMed 
    acts_upstream_of interleukin-6 production PubMed 
    acts_upstream_of interleukin-6 production PubMed 
    acts_upstream_of_or_within mast cell activation PubMed 
    acts_upstream_of_or_within mast cell activation PubMed 
    acts_upstream_of mast cell apoptotic process PubMed 
    acts_upstream_of mast cell apoptotic process PubMed 
    acts_upstream_of mast cell cytokine production PubMed 
    acts_upstream_of mast cell cytokine production PubMed 
    acts_upstream_of mast cell degranulation PubMed 
    acts_upstream_of mast cell degranulation PubMed 
    acts_upstream_of_or_within negative regulation of mast cell apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of mast cell apoptotic process PubMed 
    involved_in neutrophil activation involved in immune response  
    involved_in neutrophil activation involved in immune response PubMed 
    involved_in neutrophil chemotaxis  
    acts_upstream_of_or_within neutrophil chemotaxis PubMed 
    acts_upstream_of_or_within osteoclast differentiation PubMed 
    acts_upstream_of_or_within phagocytosis, engulfment PubMed 
    acts_upstream_of_or_within positive regulation of immune response PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-10 production PubMed 
    involved_in positive regulation of interleukin-4 production PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-6 production PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-6 production PubMed 
    acts_upstream_of_or_within positive regulation of mast cell cytokine production PubMed 
    acts_upstream_of_or_within positive regulation of mast cell cytokine production PubMed 
    acts_upstream_of_or_within positive regulation of mast cell degranulation PubMed 
    acts_upstream_of_or_within positive regulation of mast cell degranulation PubMed 
    involved_in positive regulation of phagocytosis  
    acts_upstream_of_or_within positive regulation of phagocytosis PubMed 
    acts_upstream_of_or_within positive regulation of protein localization to cell surface PubMed 
    acts_upstream_of_or_within positive regulation of protein localization to cell surface PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production PubMed 
    acts_upstream_of_or_within positive regulation of type I hypersensitivity PubMed 
    acts_upstream_of_or_within positive regulation of type III hypersensitivity PubMed 
    acts_upstream_of_or_within positive regulation of type IIa hypersensitivity PubMed 
    acts_upstream_of_or_within protein localization to plasma membrane PubMed 
    involved_in receptor internalization PubMed 
    acts_upstream_of_or_within regulation of immune response PubMed 
    involved_in regulation of platelet activation  
    involved_in regulation of platelet activation PubMed 
    involved_in serotonin secretion by platelet PubMed 
    acts_upstream_of_or_within signal transduction PubMed 
    acts_upstream_of tumor necrosis factor production PubMed 
    acts_upstream_of tumor necrosis factor production PubMed 
    Items 1 - 25 of 69
    Component Evidence Code Pubs
    part_of Fc-epsilon receptor I complex  
    part_of Fc-epsilon receptor I complex PubMed 
    part_of Fc-gamma receptor III complex  
    located_in cell surface PubMed 
    located_in cell surface  
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane PubMed 
    located_in membrane raft PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    high affinity immunoglobulin epsilon receptor subunit gamma
    Names
    Fc receptor gamma-chain
    fc-epsilon RI-gamma
    fceRI gamma
    igE Fc receptor subunit gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010185.4NP_034315.1  high affinity immunoglobulin epsilon receptor subunit gamma precursor

      See identical proteins and their annotated locations for NP_034315.1

      Status: VALIDATED

      Source sequence(s)
      BE634435, BY173505, CK791068
      Consensus CDS
      CCDS15483.1
      UniProtKB/Swiss-Prot
      P20491
      Related
      ENSMUSP00000078875.7, ENSMUST00000079957.12
      Conserved Domains (2) summary
      smart00077
      Location:6282
      ITAM; Immunoreceptor tyrosine-based activation motif
      pfam11628
      Location:2151
      TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171057141..171061918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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