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    Ctsr cathepsin R [ Mus musculus (house mouse) ]

    Gene ID: 56835, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctsrprovided by MGI
    Official Full Name
    cathepsin Rprovided by MGI
    Primary source
    MGI:MGI:1861723
    See related
    Ensembl:ENSMUSG00000055679 AllianceGenome:MGI:1861723
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to act upstream of or within protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in brain; extraembryonic component; head; and placenta. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 141.9) See more
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    Genomic context

    See Ctsr in Genome Data Viewer
    Location:
    13 B2; 13 32.67 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61307029..61312002, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (61159215..61164188, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cathepsin Q Neighboring gene STARR-seq mESC enhancer starr_34744 Neighboring gene STARR-seq mESC enhancer starr_34745 Neighboring gene zinc finger protein 930 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34746 Neighboring gene STARR-seq mESC enhancer starr_34747 Neighboring gene cathepsin 6 Neighboring gene cathepsin 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type peptidase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein catabolic process ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome ISA
    Inferred from Sequence Alignment
    more info
    PubMed 

    General protein information

    Preferred Names
    cathepsin R
    Names
    lysosomal cysteine protease

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020284.1NP_064680.1  cathepsin R precursor

      See identical proteins and their annotated locations for NP_064680.1

      Status: PROVISIONAL

      Source sequence(s)
      AF245399
      Consensus CDS
      CCDS26585.1
      UniProtKB/Swiss-Prot
      Q9JIA9
      UniProtKB/TrEMBL
      Q497X4, Q58IU7
      Related
      ENSMUSP00000021889.5, ENSMUST00000021889.6
      Conserved Domains (3) summary
      PTZ00203
      Location:15332
      PTZ00203; cathepsin L protease; Provisional
      smart00848
      Location:2987
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      cd02248
      Location:116332
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      61307029..61312002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)