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    Dapk1 death associated protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 69635, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dapk1provided by MGI
    Official Full Name
    death associated protein kinase 1provided by MGI
    Primary source
    MGI:MGI:1916885
    See related
    Ensembl:ENSMUSG00000021559 AllianceGenome:MGI:1916885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D13Ucla1; DAP-Kinase
    Summary
    Enables ATP binding activity; calmodulin binding activity; and protein kinase activity. Involved in several processes, including cellular response to type II interferon; protein phosphorylation; and regulation of NMDA receptor activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in urinary bladder cancer and uterine fibroid. Orthologous to human DAPK1 (death associated protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 29.9), lung adult (RPKM 28.7) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dapk1 in Genome Data Viewer
    Location:
    13 B2; 13 32.53 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (60749506..60911005)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (60601723..60763191)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34735 Neighboring gene predicted gene, 35333 Neighboring gene RIKEN cDNA A530001N23 gene Neighboring gene STARR-seq mESC enhancer starr_34736 Neighboring gene STARR-seq mESC enhancer starr_34737 Neighboring gene STARR-seq mESC enhancer starr_34738 Neighboring gene STARR-seq mESC enhancer starr_34740 Neighboring gene predicted gene, 35540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:60839367-60839520 Neighboring gene STARR-seq mESC enhancer starr_34741 Neighboring gene cDNA sequence BC051665 Neighboring gene cathepsin L-like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (8)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • 2310039H24Rik, 2810425C21Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin-1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydroperoxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to type II interferon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to tumor cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of NMDA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of DAPK1-calmodulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    death-associated protein kinase 1
    Names
    DAP kinase 1
    NP_001272846.1
    NP_083929.2
    NP_598823.1
    XP_006517433.1
    XP_017171087.1
    XP_030103260.1
    XP_036014050.1
    XP_036014051.1
    XP_036014052.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285917.1NP_001272846.1  death-associated protein kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_001272846.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154176, AK145922, BC060161, BQ745486, CT010498, CX244175
      Consensus CDS
      CCDS88466.1
      UniProtKB/Swiss-Prot
      Q80YE6, Q80YE7, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7
      UniProtKB/TrEMBL
      Q3UKP8
      Related
      ENSMUSP00000153607.2, ENSMUST00000226059.2
      Conserved Domains (5) summary
      PHA03095
      Location:425667
      PHA03095; ankyrin-like protein; Provisional
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:379431
      Ank_4; Ankyrin repeats (many copies)
    2. NM_029653.3NP_083929.2  death-associated protein kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_083929.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC154176, AK145922, BC060161, BQ745486, CT010498, CX244175
      Consensus CDS
      CCDS26581.1
      UniProtKB/TrEMBL
      Q3UKP8
      Related
      ENSMUSP00000076666.6, ENSMUST00000077453.13
      Conserved Domains (6) summary
      PHA03095
      Location:425667
      PHA03095; ankyrin-like protein; Provisional
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:379431
      Ank_4; Ankyrin repeats (many copies)
      cl39094
      Location:338409
      Ank_2; Ankyrin repeats (3 copies)
    3. NM_134062.2NP_598823.1  death-associated protein kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_598823.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK145922, BC060161, BQ745486, CT010498
      Consensus CDS
      CCDS26581.1
      UniProtKB/TrEMBL
      Q3UKP8
      Related
      ENSMUSP00000040825.8, ENSMUST00000044083.9
      Conserved Domains (6) summary
      PHA03095
      Location:425667
      PHA03095; ankyrin-like protein; Provisional
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:379431
      Ank_4; Ankyrin repeats (many copies)
      cl39094
      Location:338409
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      60749506..60911005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247400.2XP_030103260.1  death-associated protein kinase 1 isoform X4

      UniProtKB/Swiss-Prot
      Q80YE6, Q80YE7, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7
      UniProtKB/TrEMBL
      Q3UKP8
      Conserved Domains (5) summary
      PHA03095
      Location:425667
      PHA03095; ankyrin-like protein; Provisional
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:379431
      Ank_4; Ankyrin repeats (many copies)
    2. XM_036158159.1XP_036014052.1  death-associated protein kinase 1 isoform X5

      UniProtKB/TrEMBL
      Q3UKP8
      Conserved Domains (6) summary
      PHA03095
      Location:425667
      PHA03095; ankyrin-like protein; Provisional
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:379431
      Ank_4; Ankyrin repeats (many copies)
      cl39094
      Location:338409
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_006517370.5XP_006517433.1  death-associated protein kinase 1 isoform X4

      See identical proteins and their annotated locations for XP_006517433.1

      UniProtKB/Swiss-Prot
      Q80YE6, Q80YE7, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7
      UniProtKB/TrEMBL
      Q3UKP8
      Conserved Domains (5) summary
      PHA03095
      Location:425667
      PHA03095; ankyrin-like protein; Provisional
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:379431
      Ank_4; Ankyrin repeats (many copies)
    4. XM_017315598.3XP_017171087.1  death-associated protein kinase 1 isoform X3

      UniProtKB/TrEMBL
      Q3UKP8
      Conserved Domains (5) summary
      PHA03095
      Location:406648
      PHA03095; ankyrin-like protein; Provisional
      cd08782
      Location:12891374
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      sd00045
      Location:393423
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:360412
      Ank_4; Ankyrin repeats (many copies)
      cl21453
      Location:2256
      PKc_like; Protein Kinases, catalytic domain
    5. XM_036158158.1XP_036014051.1  death-associated protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      Q3UKP8
      Conserved Domains (6) summary
      PLN03192
      Location:537790
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd08782
      Location:13301415
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      sd00045
      Location:434464
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:401453
      Ank_4; Ankyrin repeats (many copies)
      cl21453
      Location:35297
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:450661
      Ank_2; Ankyrin repeats (3 copies)
    6. XM_036158157.1XP_036014050.1  death-associated protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      Q3UKP8
      Conserved Domains (6) summary
      PLN03192
      Location:537790
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd08782
      Location:13301415
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      sd00045
      Location:434464
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:401453
      Ank_4; Ankyrin repeats (many copies)
      cl21453
      Location:35297
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:450661
      Ank_2; Ankyrin repeats (3 copies)