U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Erbb4 erb-b2 receptor tyrosine kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 13869, updated on 9-Dec-2024

    Summary

    Official Symbol
    Erbb4provided by MGI
    Official Full Name
    erb-b2 receptor tyrosine kinase 4provided by MGI
    Primary source
    MGI:MGI:104771
    See related
    Ensembl:ENSMUSG00000062209 AllianceGenome:MGI:104771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Her4; c-erbB-4
    Summary
    Enables GABA receptor binding activity; epidermal growth factor receptor activity; and neuregulin receptor activity. Involved in several processes, including cell surface receptor signaling pathway; mammary gland development; and nervous system development. Acts upstream of or within several processes, including cellular response to epidermal growth factor stimulus; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of protein localization to cell surface. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including brain; embryo ectoderm; facial prominence; heart; and mammary gland primordium. Used to study schizophrenia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 2.3), frontal lobe adult (RPKM 2.1) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Erbb4 in Genome Data Viewer
    Location:
    1 C3; 1 33.8 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (68071063..69147756, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (68031884..69108576, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01201 Neighboring gene kinesin family member 22, pseudogene Neighboring gene STARR-seq mESC enhancer starr_01202 Neighboring gene VISTA enhancer mm148 Neighboring gene predicted gene 15669 Neighboring gene STARR-seq mESC enhancer starr_01204 Neighboring gene STARR-seq mESC enhancer starr_01205 Neighboring gene STARR-seq mESC enhancer starr_01207 Neighboring gene STARR-seq mESC enhancer starr_01208 Neighboring gene STARR-seq mESC enhancer starr_01209 Neighboring gene predicted gene, 25542 Neighboring gene STARR-seq mESC enhancer starr_01210 Neighboring gene STARR-seq mESC enhancer starr_01211 Neighboring gene STARR-positive B cell enhancer mm9_chr1:68812823-68813124 Neighboring gene STARR-seq mESC enhancer starr_01212 Neighboring gene predicted gene, 53558 Neighboring gene STARR-seq mESC enhancer starr_01213 Neighboring gene predicted gene, 51744 Neighboring gene predicted gene 8840 Neighboring gene PC-esterase domain containing 1C, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GABA receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables epidermal growth factor receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables epidermal growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hepatocyte growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuregulin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables neuregulin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuregulin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables neuregulin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ERBB2-ERBB4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ERBB2-ERBB4 signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ERBB4 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ERBB4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in ERBB4-ERBB4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ERBB4-ERBB4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in Kit signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to epidermal growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in central nervous system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within establishment of planar polarity involved in nephron morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lactation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mammary gland alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mammary gland epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial fragmentation involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in olfactory bulb interneuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein localization to cell surface IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in surfactant homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in basal plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in inhibitory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    receptor tyrosine-protein kinase erbB-4
    Names
    avian erythroblastosis oncogene B 4
    proto-oncogene-like protein c-ErbB-4
    v-erb-a erythroblastic leukemia viral oncogene homolog 4
    NP_034284.1
    XP_006495755.1
    XP_006495756.1
    XP_006495757.1
    XP_006495758.1
    XP_036015359.1
    XP_036015364.1
    XP_036015388.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010154.2NP_034284.1  receptor tyrosine-protein kinase erbB-4 precursor

      See identical proteins and their annotated locations for NP_034284.1

      Status: VALIDATED

      Source sequence(s)
      AC167658, AK144050
      Consensus CDS
      CCDS48285.1
      UniProtKB/Swiss-Prot
      Q61527
      Related
      ENSMUSP00000114123.2, ENSMUST00000121473.8
      Conserved Domains (8) summary
      cd05110
      Location:7101012
      PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
      cd12092
      Location:642685
      TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
      smart00261
      Location:549596
      FU; Furin-like repeats
      cd00064
      Location:229274
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:186332
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:55167
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:718974
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:502634
      GF_recep_IV; Growth factor receptor domain IV

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      68071063..69147756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495692.5XP_006495755.1  receptor tyrosine-protein kinase erbB-4 isoform X1

      See identical proteins and their annotated locations for XP_006495755.1

      UniProtKB/Swiss-Prot
      B2KGF5, B2KGF6, O88460, Q3UNS6, Q61527
      Related
      ENSMUSP00000112713.2, ENSMUST00000119142.8
      Conserved Domains (5) summary
      cd05110
      Location:7101012
      PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
      cd12092
      Location:642685
      TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
      pfam00757
      Location:186334
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:55165
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:502634
      GF_recep_IV; Growth factor receptor domain IV
    2. XM_006495694.5XP_006495757.1  receptor tyrosine-protein kinase erbB-4 isoform X3

      Conserved Domains (5) summary
      cd05110
      Location:7001002
      PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
      cd12092
      Location:632675
      TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
      pfam00757
      Location:186334
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:55165
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:502634
      GF_recep_IV; Growth factor receptor domain IV
    3. XM_006495693.5XP_006495756.1  receptor tyrosine-protein kinase erbB-4 isoform X2

      See identical proteins and their annotated locations for XP_006495756.1

      UniProtKB/Swiss-Prot
      Q61527
      Conserved Domains (5) summary
      cd05110
      Location:7001002
      PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
      cd12092
      Location:632675
      TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
      pfam00757
      Location:186334
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:55165
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:502634
      GF_recep_IV; Growth factor receptor domain IV
    4. XM_006495695.5XP_006495758.1  receptor tyrosine-protein kinase erbB-4 isoform X6

      UniProtKB/TrEMBL
      B2KGF7
      Conserved Domains (5) summary
      cd12092
      Location:642685
      TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
      pfam00757
      Location:186334
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:55165
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:502634
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:710829
      PKc_like; Protein Kinases, catalytic domain
    5. XM_036159471.1XP_036015364.1  receptor tyrosine-protein kinase erbB-4 isoform X5

      UniProtKB/TrEMBL
      B2KGF7
      Conserved Domains (5) summary
      cd12092
      Location:642685
      TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
      pfam00757
      Location:186332
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:55167
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:502634
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:710834
      PKc_like; Protein Kinases, catalytic domain
    6. XM_036159466.1XP_036015359.1  receptor tyrosine-protein kinase erbB-4 isoform X4

      UniProtKB/TrEMBL
      B2KGF7
      Conserved Domains (5) summary
      cd12092
      Location:642685
      TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
      pfam00757
      Location:186332
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:55167
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:502634
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:710829
      PKc_like; Protein Kinases, catalytic domain
    7. XM_036159495.1XP_036015388.1  receptor tyrosine-protein kinase erbB-4 isoform X7

      UniProtKB/TrEMBL
      B2KGF7
      Related
      ENSMUSP00000115373.2, ENSMUST00000153432.2
      Conserved Domains (3) summary
      pfam00757
      Location:186332
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:55167
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:502634
      GF_recep_IV; Growth factor receptor domain IV