U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Entpd8 ectonucleoside triphosphate diphosphohydrolase 8 [ Mus musculus (house mouse) ]

    Gene ID: 72090, updated on 9-Dec-2024

    Summary

    Official Symbol
    Entpd8provided by MGI
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 8provided by MGI
    Primary source
    MGI:MGI:1919340
    See related
    Ensembl:ENSMUSG00000036813 AllianceGenome:MGI:1919340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables nucleoside diphosphate phosphatase activity and ribonucleoside triphosphate phosphatase activity. Acts upstream of or within nucleoside diphosphate biosynthetic process and nucleoside monophosphate biosynthetic process. Located in membrane. Is expressed in esophagus; intestine; lung; and reproductive system. Orthologous to human ENTPD8 (ectonucleoside triphosphate diphosphohydrolase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 99.7), small intestine adult (RPKM 77.6) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Entpd8 in Genome Data Viewer
    Location:
    2 A3; 2 16.97 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24969308..24975731)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25079296..25085719)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor Neighboring gene microRNA 7664 Neighboring gene STARR-seq mESC enhancer starr_03956 Neighboring gene predicted gene, 39770 Neighboring gene NADPH oxidase activator 1 Neighboring gene STARR-seq mESC enhancer starr_03957 Neighboring gene VISTA enhancer mm1454 Neighboring gene predicted gene 13387 Neighboring gene Notch-regulated ankyrin repeat protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables apyrase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleoside diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribonucleoside triphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 8
    Names
    E-NTPDase 8
    NTPDase 8
    NTPDase8
    NP_082369.1
    XP_011237493.1
    XP_030107962.1
    XP_030107963.1
    XP_030107964.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028093.1NP_082369.1  ectonucleoside triphosphate diphosphohydrolase 8

      See identical proteins and their annotated locations for NP_082369.1

      Status: VALIDATED

      Source sequence(s)
      AV026718, AY364442, BB610017
      Consensus CDS
      CCDS15748.1
      UniProtKB/Swiss-Prot
      A2AJ99, Q6UQ22, Q8K0L2
      Related
      ENSMUSP00000110022.3, ENSMUST00000114380.9
      Conserved Domains (1) summary
      cl17037
      Location:34459
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24969308..24975731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239191.2XP_011237493.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1

      Conserved Domains (1) summary
      cl17037
      Location:34347
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. XM_030252103.2XP_030107963.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X3

      Related
      ENSMUST00000152326.8
      Conserved Domains (1) summary
      cl17037
      Location:3262
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    3. XM_030252104.2XP_030107964.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X4

      Conserved Domains (1) summary
      cl17037
      Location:34261
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    4. XM_030252102.2XP_030107962.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X2

      Conserved Domains (1) summary
      cl17037
      Location:1332
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily