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    Slc34a3 solute carrier family 34 (sodium phosphate), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 142681, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc34a3provided by MGI
    Official Full Name
    solute carrier family 34 (sodium phosphate), member 3provided by MGI
    Primary source
    MGI:MGI:2159410
    See related
    Ensembl:ENSMUSG00000006469 AllianceGenome:MGI:2159410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Npt2c; NptIIc; naPi-2c; Npt2c-v1
    Summary
    Enables sodium:phosphate symporter activity. Acts upstream of or within phosphate ion transport. Located in apical plasma membrane and brush border membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; and small intestine. Human ortholog(s) of this gene implicated in hereditary hypophosphatemic rickets with hypercalciuria. Orthologous to human SLC34A3 (solute carrier family 34 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward kidney adult (RPKM 74.2) See more
    Orthologs
    NEW
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    Genomic context

    See Slc34a3 in Genome Data Viewer
    Location:
    2 A3; 2 17.09 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25118909..25124282, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25228897..25234270, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sperm tail PG rich repeat containing 3 Neighboring gene ciliary microtubule inner protein 2A Neighboring gene tubulin, beta 4B class IVB Neighboring gene STARR-seq mESC enhancer starr_03963 Neighboring gene ring finger protein 224 Neighboring gene cysteine rich tail 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC159029

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables sodium:phosphate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:phosphate symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:phosphate symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sodium:phosphate symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular phosphate ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular phosphate ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphate ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphate ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium-dependent phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium-dependent phosphate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium-dependent phosphate transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in brush border IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    sodium-dependent phosphate transport protein 2C
    Names
    Na(+)-dependent phosphate cotransporter 2C
    Na(+)/Pi cotransporter 2C
    sodium-phosphate cotransporter IIC
    sodium/phosphate cotransporter 2C
    type IIc Na+/Pi-cotransporter
    type IIc NaPi-cotransporter-v1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362748.1NP_001349677.1  sodium-dependent phosphate transport protein 2C isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL732309
      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Conserved Domains (1) summary
      TIGR01013
      Location:19505
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    2. NM_080854.3NP_543130.2  sodium-dependent phosphate transport protein 2C isoform 1

      See identical proteins and their annotated locations for NP_543130.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL732309, BC125326
      Consensus CDS
      CCDS15754.1
      UniProtKB/Swiss-Prot
      Q05AC3, Q80SU6
      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Related
      ENSMUSP00000006638.8, ENSMUST00000006638.8
      Conserved Domains (1) summary
      TIGR01013
      Location:79565
      2a58; Phosphate:Na+ Symporter (PNaS) Family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25118909..25124282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497681.3XP_006497744.1  sodium-dependent phosphate transport protein 2C isoform X5

      See identical proteins and their annotated locations for XP_006497744.1

      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Conserved Domains (1) summary
      TIGR01013
      Location:19505
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    2. XM_006497683.3XP_006497746.1  sodium-dependent phosphate transport protein 2C isoform X5

      See identical proteins and their annotated locations for XP_006497746.1

      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Conserved Domains (1) summary
      TIGR01013
      Location:19505
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    3. XM_006497679.2XP_006497742.1  sodium-dependent phosphate transport protein 2C isoform X3

      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Conserved Domains (1) summary
      TIGR01013
      Location:72558
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    4. XM_006497677.2XP_006497740.1  sodium-dependent phosphate transport protein 2C isoform X2

      See identical proteins and their annotated locations for XP_006497740.1

      UniProtKB/Swiss-Prot
      Q05AC3, Q80SU6
      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Conserved Domains (1) summary
      TIGR01013
      Location:79565
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    5. XM_011239018.2XP_011237320.1  sodium-dependent phosphate transport protein 2C isoform X4

      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Conserved Domains (1) summary
      TIGR01013
      Location:87543
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    6. XM_011239017.2XP_011237319.1  sodium-dependent phosphate transport protein 2C isoform X1

      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Conserved Domains (1) summary
      TIGR01013
      Location:87573
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    7. XM_006497678.2XP_006497741.1  sodium-dependent phosphate transport protein 2C isoform X2

      See identical proteins and their annotated locations for XP_006497741.1

      UniProtKB/Swiss-Prot
      Q05AC3, Q80SU6
      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Conserved Domains (1) summary
      TIGR01013
      Location:79565
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    8. XM_017315536.2XP_017171025.1  sodium-dependent phosphate transport protein 2C isoform X1

      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Conserved Domains (1) summary
      TIGR01013
      Location:87573
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    9. XM_017315541.2XP_017171030.1  sodium-dependent phosphate transport protein 2C isoform X5

      UniProtKB/TrEMBL
      A0A0D5ZYC4
      Conserved Domains (1) summary
      TIGR01013
      Location:19505
      2a58; Phosphate:Na+ Symporter (PNaS) Family