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    Abi3 ABI family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 66610, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abi3provided by MGI
    Official Full Name
    ABI family member 3provided by MGI
    Primary source
    MGI:MGI:1913860
    See related
    Ensembl:ENSMUSG00000018381 AllianceGenome:MGI:1913860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NESH; 2210414K06Rik
    Summary
    Predicted to enable several functions, including SH3 domain binding activity; actin filament binding activity; and identical protein binding activity. Involved in defense response to tumor cell; negative regulation of lamellipodium assembly; and negative regulation of protein localization to plasma membrane. Located in lamellipodium. Part of SCAR complex. Is expressed in several structures, including genitourinary system; gut; heart ventricle; lung; and spleen. Orthologous to human ABI3 (ABI family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 38.5), duodenum adult (RPKM 25.3) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Abi3 in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95720898..95733302, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95830072..95842476, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29933 Neighboring gene STARR-seq mESC enhancer starr_30520 Neighboring gene phosphatase, orphan 1 Neighboring gene predicted gene, 38958 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:95694502-95694744 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:95695557-95695835 Neighboring gene guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 Neighboring gene RIKEN cDNA 4833417C18 gene Neighboring gene STARR-positive B cell enhancer ABC_E305 Neighboring gene predicted gene, 38959 Neighboring gene nuclear encoded tRNA glutamine 6 (anticodon TTG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to tumor cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modification of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynaptic density assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCAR complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular anatomical structure ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ABI gene family member 3
    Names
    ABI gene family, member 3
    new molecule including SH3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163464.1NP_001156936.1  ABI gene family member 3 isoform 2

      See identical proteins and their annotated locations for NP_001156936.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. These differences causes translation initiation at a downstream AUG and results an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK037144, AL593858
      UniProtKB/Swiss-Prot
      Q8BYZ1
      Conserved Domains (2) summary
      cd11826
      Location:260311
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:43114
      Abi_HHR; Abl-interactor HHR
    2. NM_025659.4NP_079935.1  ABI gene family member 3 isoform 1

      See identical proteins and their annotated locations for NP_079935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK008928, AL593858
      Consensus CDS
      CCDS25283.1
      UniProtKB/Swiss-Prot
      Q3TA46, Q6PE63, Q8BYZ1, Q9D7S4
      Related
      ENSMUSP00000061893.4, ENSMUST00000059026.10
      Conserved Domains (2) summary
      cd11826
      Location:313364
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:96159
      Abi_HHR; Abl-interactor HHR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95720898..95733302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246225.2XP_030102085.1  ABI gene family member 3 isoform X4

      Conserved Domains (2) summary
      cd11826
      Location:312363
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:96167
      Abi_HHR; Abl-interactor HHR
    2. XM_030246228.2XP_030102088.1  ABI gene family member 3 isoform X6

      Conserved Domains (2) summary
      cd11826
      Location:271321
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:96167
      Abi_HHR; Abl-interactor HHR
    3. XM_017314710.3XP_017170199.1  ABI gene family member 3 isoform X7

      UniProtKB/Swiss-Prot
      Q8BYZ1
      Conserved Domains (2) summary
      cd11826
      Location:260311
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:43114
      Abi_HHR; Abl-interactor HHR
    4. XM_017314709.2XP_017170198.1  ABI gene family member 3 isoform X3

      Conserved Domains (2) summary
      cd11826
      Location:328379
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:112183
      Abi_HHR; Abl-interactor HHR
    5. XM_006533956.3XP_006534019.1  ABI gene family member 3 isoform X5

      Conserved Domains (2) summary
      cd11826
      Location:288338
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:112183
      Abi_HHR; Abl-interactor HHR
    6. XM_017314708.1XP_017170197.1  ABI gene family member 3 isoform X2

      Conserved Domains (2) summary
      cd11826
      Location:328379
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:112183
      Abi_HHR; Abl-interactor HHR
    7. XM_017314707.1XP_017170196.1  ABI gene family member 3 isoform X1

      Conserved Domains (2) summary
      cd11826
      Location:329380
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:112183
      Abi_HHR; Abl-interactor HHR