U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    F8a factor 8-associated gene A [ Mus musculus (house mouse) ]

    Gene ID: 14070, updated on 9-Dec-2024

    Summary

    Official Symbol
    F8aprovided by MGI
    Official Full Name
    factor 8-associated gene Aprovided by MGI
    Primary source
    MGI:MGI:95474
    See related
    Ensembl:ENSMUSG00000078317 AllianceGenome:MGI:95474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F8a1; DXUcsf1
    Summary
    Predicted to be involved in negative regulation of proteasomal protein catabolic process and vesicle cytoskeletal trafficking. Located in cytoplasm and nuclear body. Is expressed in several structures, including gut; liver lobe; lower urinary tract; pharyngo-tympanic tube; and submandibular gland primordium. Orthologous to human F8A1 (coagulation factor VIII associated 1); F8A2 (coagulation factor VIII associated 2); and F8A3 (coagulation factor VIII associated 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See F8a in Genome Data Viewer
    Location:
    X A7.3; X 37.29 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72271912..72274401)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73228306..73230795)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene X-linked lymphocyte-regulated 3B Neighboring gene X-linked lymphocyte-regulated 4B Neighboring gene X-linked lymphocyte-regulated 4C Neighboring gene X-linked lymphocyte-regulated 3C

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vesicle cytoskeletal trafficking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle cytoskeletal trafficking ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle cytoskeletal trafficking ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    40-kDa huntingtin-associated protein
    Names
    Factor VIII associated protein
    cpG island protein
    factor VIII intron 22 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007978.3NP_032004.2  40-kDa huntingtin-associated protein

      See identical proteins and their annotated locations for NP_032004.2

      Status: VALIDATED

      Source sequence(s)
      AK054140
      Consensus CDS
      CCDS41011.1
      UniProtKB/Swiss-Prot
      Q00558, Q3TLS9, Q9JJQ6
      UniProtKB/TrEMBL
      Q8CCG9
      Related
      ENSMUSP00000100743.3, ENSMUST00000105111.4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72271912..72274401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)