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    Acad10 acyl-Coenzyme A dehydrogenase family, member 10 [ Mus musculus (house mouse) ]

    Gene ID: 71985, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Acad10provided by MGI
    Official Full Name
    acyl-Coenzyme A dehydrogenase family, member 10provided by MGI
    Primary source
    MGI:MGI:1919235
    See related
    Ensembl:ENSMUSG00000029456 AllianceGenome:MGI:1919235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410021P16Rik
    Summary
    Predicted to enable acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Orthologous to human ACAD10 (acyl-CoA dehydrogenase family member 10). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in kidney adult (RPKM 23.5), liver adult (RPKM 10.5) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acad10 in Genome Data Viewer
    Location:
    5 F; 5 61.88 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121759089..121798642, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121621026..121660603, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14260 Neighboring gene aldehyde dehydrogenase 2, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_14261 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12 Neighboring gene BRCA1 associated protein Neighboring gene ataxin 2 Neighboring gene STARR-seq mESC enhancer starr_14264 Neighboring gene microRNA 7031 Neighboring gene SH2B adaptor protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus. Bloom K, et al. J Inherit Metab Dis, 2018 Jan. PMID 28120165, Free PMC Article
    2. ACAD10 protein expression and Neurobehavioral assessment of Acad10-deficient mice. Bloom K, et al. PLoS One, 2020. PMID 33301490, Free PMC Article
    3. The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10. Shim SM, et al. Autophagy, 2023 Jun. PMID 36184612, Free PMC Article
    4. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article
    5. Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue. Chavez JD, et al. Cell Syst, 2018 Jan 24. PMID 29199018, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    acyl-CoA dehydrogenase family member 10
    Names
    ACAD-10
    NP_082313.2
    XP_006530521.1
    XP_006530522.1
    XP_006530523.1
    XP_006530524.1
    XP_006530525.1
    XP_006530526.1
    XP_030110677.1
    XP_030110678.1
    XP_036021399.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028037.4 → NP_082313.2  acyl-CoA dehydrogenase family member 10

      Status: VALIDATED

      Source sequence(s)
      AK050332, CJ136937
      Consensus CDS
      CCDS51643.1
      UniProtKB/Swiss-Prot
      Q8BWQ0, Q8K313, Q8K370
      Related
      ENSMUSP00000107400.2, ENSMUST00000111770.2
      Conserved Domains (2) summary
      PLN02876
      Location:257 → 1056
      PLN02876; acyl-CoA dehydrogenase
      TIGR02247
      Location:41 → 247
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121759089..121798642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530459.3 → XP_006530522.1  acyl-CoA dehydrogenase family member 10 isoform X2

      Conserved Domains (2) summary
      PLN02876
      Location:249 → 1048
      PLN02876; acyl-CoA dehydrogenase
      TIGR02247
      Location:41 → 239
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

    2. XM_006530458.5 → XP_006530521.1  acyl-CoA dehydrogenase family member 10 isoform X1

      UniProtKB/Swiss-Prot
      Q8BWQ0, Q8K313, Q8K370
      Related
      ENSMUSP00000031412.6, ENSMUST00000031412.12
      Conserved Domains (2) summary
      PLN02876
      Location:257 → 1056
      PLN02876; acyl-CoA dehydrogenase
      TIGR02247
      Location:41 → 247
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

    3. XM_030254817.2 → XP_030110677.1  acyl-CoA dehydrogenase family member 10 isoform X3

      Conserved Domains (2) summary
      PLN02876
      Location:161 → 960
      PLN02876; acyl-CoA dehydrogenase
      TIGR02247
      Location:17 → 151
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

    4. XM_006530460.5 → XP_006530523.1  acyl-CoA dehydrogenase family member 10 isoform X4

      UniProtKB/Swiss-Prot
      Q8K370
      Conserved Domains (2) summary
      PLN02876
      Location:120 → 919
      PLN02876; acyl-CoA dehydrogenase
      TIGR02247
      Location:1 → 110
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

    5. XM_036165506.1 → XP_036021399.1  acyl-CoA dehydrogenase family member 10 isoform X4

      Conserved Domains (2) summary
      PLN02876
      Location:120 → 919
      PLN02876; acyl-CoA dehydrogenase
      TIGR02247
      Location:1 → 110
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

    6. XM_030254818.2 → XP_030110678.1  acyl-CoA dehydrogenase family member 10 isoform X5

      UniProtKB/TrEMBL
      Q9CRH8
      Conserved Domains (1) summary
      PLN02876
      Location:16 → 658
      PLN02876; acyl-CoA dehydrogenase

    7. XM_006530463.3 → XP_006530526.1  acyl-CoA dehydrogenase family member 10 isoform X6

      Conserved Domains (2) summary
      TIGR02247
      Location:41 → 58
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
      cl09933
      Location:154 → 547
      ACAD; Acyl-CoA dehydrogenase

    8. XM_006530462.1 → XP_006530525.1  acyl-CoA dehydrogenase family member 10 isoform X5

      UniProtKB/TrEMBL
      Q9CRH8
      Conserved Domains (1) summary
      PLN02876
      Location:16 → 658
      PLN02876; acyl-CoA dehydrogenase

    9. XM_006530461.5 → XP_006530524.1  acyl-CoA dehydrogenase family member 10 isoform X4

      UniProtKB/Swiss-Prot
      Q8K370
      Conserved Domains (2) summary
      PLN02876
      Location:120 → 919
      PLN02876; acyl-CoA dehydrogenase
      TIGR02247
      Location:1 → 110
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K370.1 GenPept UniProtKB/Swiss-Prot:Q8K370

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