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    Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha [ Mus musculus (house mouse) ]

    Gene ID: 13024, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctla2aprovided by MGI
    Official Full Name
    cytotoxic T lymphocyte-associated protein 2 alphaprovided by MGI
    Primary source
    MGI:MGI:88554
    See related
    Ensembl:ENSMUSG00000044258 AllianceGenome:MGI:88554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ctla-2a
    Summary
    Acts upstream of or within negative regulation of inflammatory response; negative regulation of protein processing; and regulation of regulatory T cell differentiation. Located in dendrite. Is expressed in several structures, including blood; cerebral cortex; extraembryonic component; genitourinary system; and lung. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 179.4) and lung adult (RPKM 12.9) See more
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    Genomic context

    See Ctla2a in Genome Data Viewer
    Location:
    13 B2; 13 32.56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61081969..61084439, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (60934155..60936625, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cytotoxic T lymphocyte-associated protein 2 beta Neighboring gene trophoblast specific protein beta Neighboring gene trophoblast specific protein alpha Neighboring gene predicted gene, 40976 Neighboring gene predicted gene, 40975

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145799.1NP_001139271.1  protein CTLA-2-alpha isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AA451288, AK018801, AK132290
      UniProtKB/TrEMBL
      A0A286YDF0
      Conserved Domains (1) summary
      smart00848
      Location:1674
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    2. NM_007796.2NP_031822.2  protein CTLA-2-alpha isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK132290, AK167433, BB574774
      Consensus CDS
      CCDS49290.1
      UniProtKB/Swiss-Prot
      P12399, Q91V07
      UniProtKB/TrEMBL
      A0A286YDF0
      Related
      ENSMUSP00000021880.10, ENSMUST00000021880.10
      Conserved Domains (1) summary
      smart00848
      Location:4098
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      61081969..61084439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)