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    Gcdh glutaryl-Coenzyme A dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 270076, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gcdhprovided by MGI
    Official Full Name
    glutaryl-Coenzyme A dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:104541
    See related
    Ensembl:ENSMUSG00000003809 AllianceGenome:MGI:104541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCD; 9030411L18
    Summary
    Predicted to enable fatty-acyl-CoA binding activity; flavin adenine dinucleotide binding activity; and glutaryl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase and fatty-acyl-CoA biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study glutaric acidemia I. Human ortholog(s) of this gene implicated in glutaric acidemia I. Orthologous to human GCDH (glutaryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 212.2), kidney adult (RPKM 105.6) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gcdh in Genome Data Viewer
    Location:
    8 C3; 8 41.28 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85613016..85629378, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84886387..84893921, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700122E12 gene Neighboring gene predicted gene 5911 Neighboring gene phenylalanyl-tRNA synthetase, alpha subunit Neighboring gene STARR-positive B cell enhancer ABC_E11391 Neighboring gene microRNA 7069 Neighboring gene synaptonemal complex central element protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E1763 Neighboring gene predicted gene, 39213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87427053-87427162 Neighboring gene STARR-positive B cell enhancer ABC_E1373 Neighboring gene Kruppel-like transcription factor 1 (erythroid) Neighboring gene deoxyribonuclease II alpha Neighboring gene predicted gene, 38426 Neighboring gene microtubule associated serine/threonine kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutaryl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutaryl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutaryl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty-acyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tryptophan metabolic process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutaryl-CoA dehydrogenase, mitochondrial
    NP_001038209.2
    NP_032123.3
    XP_036009971.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044744.1NP_001038209.2  glutaryl-CoA dehydrogenase, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC161765, AI181022, AK078866, AU080952
      Consensus CDS
      CCDS22482.2
      UniProtKB/TrEMBL
      A0A0A0MQ68, A0A1S6GWJ2
      Related
      ENSMUSP00000105367.2, ENSMUST00000109745.8
      Conserved Domains (1) summary
      cd01151
      Location:57443
      GCD; Glutaryl-CoA dehydrogenase
    2. NM_008097.2NP_032123.3  glutaryl-CoA dehydrogenase, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC161765, AI181022, AK078866, AK165406
      Consensus CDS
      CCDS22482.2
      UniProtKB/TrEMBL
      A0A0A0MQ68, A0A1S6GWJ2
      Related
      ENSMUSP00000003907.9, ENSMUST00000003907.14
      Conserved Domains (1) summary
      cd01151
      Location:57443
      GCD; Glutaryl-CoA dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85613016..85629378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154078.1XP_036009971.1  glutaryl-CoA dehydrogenase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQ68, A0A1S6GWJ2
      Conserved Domains (1) summary
      cd01151
      Location:57443
      GCD; Glutaryl-CoA dehydrogenase