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    Igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 140486, updated on 27-Nov-2024

    Summary

    Official Symbol
    Igf2bp1provided by MGI
    Official Full Name
    insulin-like growth factor 2 mRNA binding protein 1provided by MGI
    Primary source
    MGI:MGI:1890357
    See related
    Ensembl:ENSMUSG00000013415 AllianceGenome:MGI:1890357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IMP1; Zbp1; Crdbp; ZBP-1; CRD-BP; Neilsen; D11Moh45; mir-3063; D11Moh40e; D030026A21Rik
    Summary
    Predicted to enable N6-methyladenosine-containing RNA reader activity; mRNA binding activity; and translation regulator activity. Acts upstream of or within neuronal stem cell population maintenance and pallium cell proliferation in forebrain. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; dendritic spine; and neuronal cell body. Predicted to be part of CRD-mediated mRNA stability complex and ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; eye; gonad; intestine; and limb. Orthologous to human IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 17.9), placenta adult (RPKM 10.3) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Igf2bp1 in Genome Data Viewer
    Location:
    11 D; 11 59.08 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95847989..95896770, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95957163..96005944, complement)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N6-methyladenosine-containing RNA reader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N6-methyladenosine-containing RNA reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in CRD-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in CRD-mediated mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in RNA localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendrite arborization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite arborization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pallium cell proliferation in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA stability involved in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA stability involved in response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of CRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of CRD-mediated mRNA stability complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    insulin-like growth factor 2 mRNA-binding protein 1
    Names
    IGF-II mRNA-binding protein 1
    IGF2 mRNA-binding protein 1
    VICKZ family member 1
    coding region determinant binding protein
    insulin-like growth factor 2 mRNA binding protein 1 dN CRDBP-2
    insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP
    insulin-like growth factor 2, binding protein 1
    zipcode binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401454.1NP_001388383.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603682, AL606704
    2. NM_001401455.1NP_001388384.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL603682, AL606704
    3. NM_001401456.1NP_001388385.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL603682, AL606704
      UniProtKB/TrEMBL
      A0A0H3XWX3
    4. NM_001401457.1NP_001388386.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL603682, AL606704
      UniProtKB/TrEMBL
      A0A0H3XWX3
    5. NM_009951.4NP_034081.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_034081.1

      Status: VALIDATED

      Source sequence(s)
      AL603682, AL606704
      Consensus CDS
      CCDS25286.1
      UniProtKB/Swiss-Prot
      O88477, Q80US9, Q8BRH1
      Related
      ENSMUSP00000013559.3, ENSMUST00000013559.3
      Conserved Domains (4) summary
      cd00105
      Location:279344
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd12625
      Location:177
      RRM1_IGF2BP1; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
      cd12628
      Location:81156
      RRM2_IGF2BP1; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
      pfam00013
      Location:408471
      KH_1; KH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95847989..95896770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)