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    Gip gastric inhibitory polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 14607, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gipprovided by MGI
    Official Full Name
    gastric inhibitory polypeptideprovided by MGI
    Primary source
    MGI:MGI:107504
    See related
    Ensembl:ENSMUSG00000014351 AllianceGenome:MGI:107504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes an incretin hormone that belongs to the glucagon superfamily. The encoded preproprotein undergoes proteolytic processing to generate mature peptides that function as potent stimulators of insulin secretion and inhibit gastric acid secretion. Transgenic mice overexpressing the encoded protein exhibit a significant increase in the expression of markers of bone formation, a decrease in the expression of markers of bone resorption and, an increase in the bone mass. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in duodenum adult (RPKM 12.2), large intestine adult (RPKM 8.5) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gip in Genome Data Viewer
    Location:
    11 D; 11 59.21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95915358..95921657)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96024532..96030831)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24725 Neighboring gene STARR-seq mESC enhancer starr_30524 Neighboring gene insulin-like growth factor 2 mRNA binding protein 1 Neighboring gene microRNA 3063 Neighboring gene STARR-seq mESC enhancer starr_30526 Neighboring gene STARR-seq mESC enhancer starr_30529 Neighboring gene STARR-seq mESC enhancer starr_30530 Neighboring gene predicted gene, 24949 Neighboring gene SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC129268, MGC129269

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gastric inhibitory polypeptide receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables gastric inhibitory polypeptide receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucagon receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult locomotory behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in digestive system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within exploration behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gastric inhibitory peptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gastric inhibitory peptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of D-glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to acidic pH IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amino acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to selenium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sensory perception of pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in triglyceride homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    gastric inhibitory polypeptide
    Names
    glucose-dependent insulinotropic polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008119.2NP_032145.2  gastric inhibitory polypeptide preproprotein

      See identical proteins and their annotated locations for NP_032145.2

      Status: REVIEWED

      Source sequence(s)
      AK008308
      Consensus CDS
      CCDS25287.1
      UniProtKB/Swiss-Prot
      P48756, Q9D887
      UniProtKB/TrEMBL
      Q3SXG6
      Related
      ENSMUSP00000099446.4, ENSMUST00000103157.10
      Conserved Domains (1) summary
      pfam00123
      Location:4471
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95915358..95921657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532225.4XP_006532288.1  gastric inhibitory polypeptide isoform X1

      See identical proteins and their annotated locations for XP_006532288.1

      UniProtKB/Swiss-Prot
      P48756, Q9D887
      UniProtKB/TrEMBL
      Q3SXG6
      Related
      ENSMUSP00000099445.2, ENSMUST00000103156.2
      Conserved Domains (1) summary
      pfam00123
      Location:4471
      Hormone_2; Peptide hormone
    2. XM_006532224.4XP_006532287.1  gastric inhibitory polypeptide isoform X1

      See identical proteins and their annotated locations for XP_006532287.1

      UniProtKB/Swiss-Prot
      P48756, Q9D887
      UniProtKB/TrEMBL
      Q3SXG6
      Conserved Domains (1) summary
      pfam00123
      Location:4471
      Hormone_2; Peptide hormone