U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ctla2b cytotoxic T lymphocyte-associated protein 2 beta [ Mus musculus (house mouse) ]

    Gene ID: 13025, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ctla2bprovided by MGI
    Official Full Name
    cytotoxic T lymphocyte-associated protein 2 betaprovided by MGI
    Primary source
    MGI:MGI:88555
    See related
    Ensembl:ENSMUSG00000074874 AllianceGenome:MGI:88555
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ctla-2b
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity. Is expressed in several structures, including blood; extraembryonic component; female reproductive system; and lung. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 17.6), liver E18 (RPKM 2.8) and 9 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ctla2b in Genome Data Viewer
    Location:
    13 B2; 13 32.53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61043165..61045269, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (60895351..60897934, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cathepsin L-like 3 Neighboring gene STARR-seq mESC enhancer starr_34742 Neighboring gene RIKEN cDNA 4930486L24 gene Neighboring gene STARR-seq mESC enhancer starr_34743 Neighboring gene trophoblast specific protein beta Neighboring gene cytotoxic T lymphocyte-associated protein 2 alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145801.2NP_001139273.1  protein CTLA-2-beta isoform b

      See identical proteins and their annotated locations for NP_001139273.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC160962, CT010498
      Consensus CDS
      CCDS49288.1
      UniProtKB/TrEMBL
      A0A0R4J245, A0A286YD17
      Related
      ENSMUSP00000131083.2, ENSMUST00000171347.9
      Conserved Domains (1) summary
      smart00848
      Location:1674
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    2. NM_001428483.1NP_001415412.1  protein CTLA-2-beta isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160962, CT010498
      UniProtKB/Swiss-Prot
      P12400, Q3UBK9, Q541S2
    3. NM_007797.2NP_031823.1  protein CTLA-2-beta isoform a

      See identical proteins and their annotated locations for NP_031823.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
      Source sequence(s)
      AC160962, CT010498
      Consensus CDS
      CCDS49289.1
      UniProtKB/Swiss-Prot
      P12400, Q3UBK9, Q541S2
      UniProtKB/TrEMBL
      A0A286YD17
      Related
      ENSMUSP00000021884.9, ENSMUST00000021884.10
      Conserved Domains (1) summary
      smart00848
      Location:1674
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    RNA

    1. NR_190375.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC160962, CT010498

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      61043165..61045269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244472.2XP_011242774.1  protein CTLA-2-beta isoform X1

      Conserved Domains (1) summary
      smart00848
      Location:1674
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    RNA

    1. XR_382421.4 RNA Sequence