U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dpcd deleted in primary ciliary dyskinesia [ Mus musculus (house mouse) ]

    Gene ID: 226162, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dpcdprovided by MGI
    Official Full Name
    deleted in primary ciliary dyskinesiaprovided by MGI
    Primary source
    MGI:MGI:1924407
    See related
    Ensembl:ENSMUSG00000041035 AllianceGenome:MGI:1924407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ndac; Gm17018
    Summary
    Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and ventricular system development. Predicted to be located in extracellular region. Used to study hydrocephalus and primary ciliary dyskinesia. Orthologous to human DPCD (deleted in primary ciliary dyskinesia homolog (mouse)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 12.3), frontal lobe adult (RPKM 12.2) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dpcd in Genome Data Viewer
    Location:
    19 C3; 19 38.75 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45549018..45566728)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45560583..45578289)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene beta-transducin repeat containing protein Neighboring gene ribosomal protein L6 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45602595-45602796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45634643-45634844 Neighboring gene STARR-positive B cell enhancer ABC_E9999 Neighboring gene predicted gene, 41856 Neighboring gene predicted gene, 19639 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45652022-45652175 Neighboring gene polymerase (DNA directed), lambda Neighboring gene AmnSINE1 enhancer AS071 Neighboring gene F-box and WD-40 domain protein 4 Neighboring gene STARR-seq mESC enhancer starr_46281 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45758150-45758404 Neighboring gene CR4 enhancer downstream of Fgf8 Neighboring gene RIKEN cDNA 4933429K18 gene Neighboring gene CR2 enhancer downstream of Fgf8 Neighboring gene Fgf8 enhancer CR1 Neighboring gene fibroblast growth factor 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein DPCD
    Names
    neighbor of Dac

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356947.1NP_001343876.1  protein DPCD isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, resulting in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a novel N-terminus, and is shorter than isoform 1.
      Source sequence(s)
      AK077347, BB656836, BC027559, BQ032258
      Conserved Domains (1) summary
      pfam14913
      Location:28135
      DPCD; DPCD protein family
    2. NM_172639.3NP_766227.1  protein DPCD isoform 1

      See identical proteins and their annotated locations for NP_766227.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC126454, AK077347, BB656836, BQ032258
      Consensus CDS
      CCDS29862.1
      UniProtKB/Swiss-Prot
      Q8BPA8, Q8K1L8
      Related
      ENSMUSP00000045683.8, ENSMUST00000047057.9
      Conserved Domains (1) summary
      pfam14913
      Location:6195
      DPCD; DPCD protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45549018..45566728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250901.2XP_030106761.1  protein DPCD isoform X2

      Conserved Domains (1) summary
      pfam14913
      Location:28135
      DPCD; DPCD protein family
    2. XM_011247238.4XP_011245540.1  protein DPCD isoform X1

      See identical proteins and their annotated locations for XP_011245540.1

      Conserved Domains (1) summary
      pfam14913
      Location:2170
      DPCD; DPCD protein family