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    Tubb4b tubulin, beta 4B class IVB [ Mus musculus (house mouse) ]

    Gene ID: 227613, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tubb4bprovided by MGI
    Official Full Name
    tubulin, beta 4B class IVBprovided by MGI
    Primary source
    MGI:MGI:1915472
    See related
    Ensembl:ENSMUSG00000036752 AllianceGenome:MGI:1915472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tubb2c; Tubb2c1; 4930542G03Rik
    Summary
    Predicted to enable GTP binding activity and double-stranded RNA binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in flagellated sperm motility. Located in myelin sheath. Is active in sperm flagellum. Is expressed in brain ependyma; epithelial layer of oviduct; germ cell of testis; nasal epithelium; and respiratory system epithelium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness. Orthologous to human TUBB4B (tubulin beta 4B class IVb). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 1044.7), liver E14 (RPKM 404.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tubb4b in Genome Data Viewer
    Location:
    2 A3; 2 17.08 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25112170..25114714, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25222158..25224702, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene negative elongation factor complex member B Neighboring gene predicted gene, 22572 Neighboring gene sperm tail PG rich repeat containing 3 Neighboring gene ciliary microtubule inner protein 2A Neighboring gene STARR-seq mESC enhancer starr_03963 Neighboring gene solute carrier family 34 (sodium phosphate), member 3 Neighboring gene ring finger protein 224

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC6713, MGC28623, MGC101937

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in axonemal microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of tubulin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    tubulin beta-4B chain
    Names
    novel tubulin protein
    tubulin beta-2C chain
    tubulin, beta 2C
    tubulin, beta 2c1
    tubulin, beta, 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146116.2NP_666228.1  tubulin beta-4B chain

      See identical proteins and their annotated locations for NP_666228.1

      Status: VALIDATED

      Source sequence(s)
      AK167022, AL732309, CJ309661
      Consensus CDS
      CCDS15753.1
      UniProtKB/Swiss-Prot
      P68372, Q3TKF0, Q3UJ73, Q99JZ6
      UniProtKB/TrEMBL
      Q3U9U3
      Related
      ENSMUSP00000042342.5, ENSMUST00000043584.5
      Conserved Domains (1) summary
      PLN00220
      Location:1427
      PLN00220; tubulin beta chain; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25112170..25114714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)