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    TMEM105 TMEM105 long non-coding RNA [ Homo sapiens (human) ]

    Gene ID: 284186, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMEM105provided by HGNC
    Official Full Name
    TMEM105 long non-coding RNAprovided by HGNC
    Primary source
    HGNC:HGNC:26794
    See related
    Ensembl:ENSG00000185332 AllianceGenome:HGNC:26794
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See TMEM105 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81311265..81330674, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82223511..82242919, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79285065..79304474, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904082 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79273333-79273505 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5937 Neighboring gene long intergenic non-protein coding RNA 482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79291988-79292526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79302243-79302814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79302815-79303386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79303387-79303956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79305100-79305670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79305671-79306241 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79313044-79313992 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79319562-79319850 Neighboring gene regulator of early neurogenesis 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79322101-79322738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79339241-79339828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79339829-79340414 Neighboring gene uncharacterized LOC124904083

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208. Han J, et al. Cell Death Dis, 2023 Feb 3. PMID 36737428, Free PMC Article
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208.
      Title: Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Other Names

    • transmembrane protein 105

    Clone Names

    • FLJ38792

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_165247.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC027601
      Related
      ENST00000650606.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81311265..81330674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82223511..82242919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178520.3: Suppressed sequence

      Description
      NM_178520.3: This RefSeq was removed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N8V8.1 GenPept UniProtKB/Swiss-Prot:Q8N8V8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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