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    P2RY2 purinergic receptor P2Y2 [ Homo sapiens (human) ]

    Gene ID: 5029, updated on 10-Dec-2024

    Summary

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    Official Symbol
    P2RY2provided by HGNC
    Official Full Name
    purinergic receptor P2Y2provided by HGNC
    Primary source
    HGNC:HGNC:8541
    See related
    Ensembl:ENSG00000175591 MIM:600041; AllianceGenome:HGNC:8541
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R
    Summary
    The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
    Expression
    Broad expression in esophagus (RPKM 5.5), thyroid (RPKM 2.6) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See P2RY2 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (73218281..73242427)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (73146472..73170656)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72929326..72953472)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5224 Neighboring gene imatinib upregulated ABL suppressing lncRNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5226 Neighboring gene Sharpr-MPRA regulatory region 14106 Neighboring gene uncharacterized LOC124902709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72929160-72929878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72929879-72930597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5227 Neighboring gene Sharpr-MPRA regulatory region 2548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72951367-72952117 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72953516-72954262 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:72959838-72961037 Neighboring gene uncharacterized LOC105369382 Neighboring gene olfactory receptor family 8 subfamily R member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Loss of P2Y₂ nucleotide receptors enhances early pathology in the TgCRND8 mouse model of Alzheimer's disease. Ajit D, et al. Mol Neurobiol, 2014 Apr. PMID 24193664, Free PMC Article
    2. Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro. Kukulski F, et al. Mol Immunol, 2010 Feb. PMID 20022380, Free PMC Article
    3. Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology. Lai MK, et al. J Neural Transm (Vienna), 2008 Aug. PMID 18506388
    4. [Nucleotide receptors and actin cytoskeleton dynamics]. Kłopocka W, et al. Postepy Biochem, 2014. PMID 25807824
    5. Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor. Meshki J, et al. Am J Physiol Cell Physiol, 2004 Feb. PMID 14613890

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The P2Y2 receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.
      Title: The P2Y(2) receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.
    2. AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer.
      Title: AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer.
    3. P2Y2R-mediated transactivation of VEGFR2 through Src phosphorylation is associated with ESM-1 overexpression in radiotherapy-resistant-triple negative breast cancer cells.
      Title: P2Y(2)R‑mediated transactivation of VEGFR2 through Src phosphorylation is associated with ESM‑1 overexpression in radiotherapy‑resistant‑triple negative breast cancer cells.
    4. Aberrant Adenosine Triphosphate Release and Impairment of P2Y2-Mediated Signaling in Sarcoglycanopathies.
      Title: Aberrant Adenosine Triphosphate Release and Impairment of P2Y2-Mediated Signaling in Sarcoglycanopathies.
    5. Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization.
      Title: Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization.
    6. Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension.
      Title: Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension.
    7. Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2.
      Title: Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2.
    8. Autocrine regulation of wound healing by ATP release and P2Y2 receptor activation.
      Title: Autocrine regulation of wound healing by ATP release and P2Y(2) receptor activation.
    9. NLRC4, ASC and Caspase-1 Are Inflammasome Components that Are Mediated by P2Y2R Activation in Breast Cancer Cells.
      Title: NLRC4, ASC and Caspase-1 Are Inflammasome Components that Are Mediated by P2Y(2)R Activation in Breast Cancer Cells.
    10. these findings reveal the roles of the P2RY2 in Pancreatic Ductal Adenocarcinoma metabolic reprogramming, suggesting that P2RY2 might be a potential metabolic therapeutic target for Pancreatic Ductal Adenocarcinoma.
      Title: Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis.
    Submit: New GeneRIF Correction See all GeneRIFs (106)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
    EBI GWAS Catalog
    Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37408, MGC20088, MGC40010, DKFZp686H09192

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables A1 adenosine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled UTP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to ATP TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular monoatomic ion homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mucus secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    P2Y purinoceptor 2
    Names
    ATP receptor
    P2U nucleotide receptor
    P2U purinoceptor 1
    P2U receptor 1
    purinergic receptor P2Y, G-protein coupled, 2
    purinoceptor P2Y2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002564.4 → NP_002555.4  P2Y purinoceptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP002761
      Consensus CDS
      CCDS8219.1
      UniProtKB/Swiss-Prot
      B2R9W3, P41231, Q96EM8
      Related
      ENSP00000377222.2, ENST00000393597.7
      Conserved Domains (1) summary
      cd15373
      Location:34 → 317
      7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_176071.3 → NP_788085.3  P2Y purinoceptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP002761
      Consensus CDS
      CCDS8219.1
      UniProtKB/Swiss-Prot
      B2R9W3, P41231, Q96EM8
      Related
      ENSP00000377221.2, ENST00000393596.2
      Conserved Domains (1) summary
      cd15373
      Location:34 → 317
      7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_176072.3 → NP_788086.3  P2Y purinoceptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP002761
      Consensus CDS
      CCDS8219.1
      UniProtKB/Swiss-Prot
      B2R9W3, P41231, Q96EM8
      Related
      ENSP00000310305.2, ENST00000311131.6
      Conserved Domains (1) summary
      cd15373
      Location:34 → 317
      7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      73218281..73242427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      73146472..73170656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41231.4 GenPept UniProtKB/Swiss-Prot:P41231

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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