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    OCM2 oncomodulin 2 [ Homo sapiens (human) ]

    Gene ID: 4951, updated on 10-Dec-2024

    Summary

    Official Symbol
    OCM2provided by HGNC
    Official Full Name
    oncomodulin 2provided by HGNC
    Primary source
    HGNC:HGNC:34396
    See related
    Ensembl:ENSG00000135175 MIM:620522; AllianceGenome:HGNC:34396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OM; OCM
    Summary
    This gene is similar to the oncomodulin gene, a high-affinity calcium ion-binding protein that belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: There are two oncomodulin-like loci on chromosome 7 (GeneIDs 4951 and 654231). The nomenclature for the p and q arm locations was modified to agree with reports (including PMID: 1559707) that place the OCM gene on the p arm. [18 Jun 2007]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See OCM2 in Genome Data Viewer
    Location:
    7q21.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (97984687..97990196, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (99214784..99220320, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (97613999..97619508, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CZ1P-ASNS readthrough Neighboring gene CCZ1P-OR7E38P readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18389 Neighboring gene olfactory receptor family 7 subfamily E member 38 pseudogene Neighboring gene CCZ1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 478, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:97652101-97652600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:97663350-97663858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:97663859-97664366 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:97677616-97678116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:97678117-97678617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:97761703-97762203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26304 Neighboring gene lemur tyrosine kinase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:97792559-97793068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:97793069-97793577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:97794853-97795370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:97795371-97795886 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:97822203-97822367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26305

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (31 hits/1123 screens)

    EBI GWAS Catalog

    Description
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    putative oncomodulin-2
    Names
    parvalbumin beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006188.4NP_006179.2  putative oncomodulin-2

      See identical proteins and their annotated locations for NP_006179.2

      Status: VALIDATED

      Source sequence(s)
      AC004967
      Consensus CDS
      CCDS5653.1
      UniProtKB/Swiss-Prot
      P0CE71, P32930, Q6ISI5, Q75MW0
      Related
      ENSP00000257627.4, ENST00000257627.5
      Conserved Domains (1) summary
      cd16255
      Location:9109
      EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      97984687..97990196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      99214784..99220320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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