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    CD46 CD46 molecule [ Homo sapiens (human) ]

    Gene ID: 4179, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CD46provided by HGNC
    Official Full Name
    CD46 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:6953
    See related
    Ensembl:ENSG00000117335 MIM:120920; AllianceGenome:HGNC:6953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCP; TLX; AHUS2; MIC10; TRA2.10
    Summary
    The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in adrenal (RPKM 99.0), placenta (RPKM 71.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CD46 in Genome Data Viewer
    Location:
    1q32.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (207752038..207795516)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206998784..207042279)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207925383..207968861)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene complement C3b/C4b receptor 1 like Neighboring gene complement C3b/C4b receptor 1 (Knops blood group) pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207903492-207904170 Neighboring gene CRISPRi-validated cis-regulatory element chr1.11362 Neighboring gene Sharpr-MPRA regulatory region 12474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2449 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:207925929-207926286 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207935554-207936354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207936355-207937153 Neighboring gene cell division cycle associated 4 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2452 Neighboring gene MIR29B2 and MIR29C host gene Neighboring gene microRNA 29b-2 Neighboring gene microRNA 29c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells. Elward K, et al. J Biol Chem, 2005 Oct 28. PMID 16087667
    2. Structural variations in species B adenovirus fibers impact CD46 association. Pache L, et al. J Virol, 2008 Aug. PMID 18524830, Free PMC Article
    3. Inherited deficiency of membrane cofactor protein expression and varying manifestations of recurrent atypical hemolytic uremic syndrome in a sibling pair. Couzi L, et al. Am J Kidney Dis, 2008 Aug. PMID 18514989
    4. Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor. Fleischli C, et al. J Gen Virol, 2007 Nov. PMID 17947513
    5. Recurrence of HUS due to CD46/MCP mutation after renal transplantation: a role for endothelial microchimerism. Frémeaux-Bacchi V, et al. Am J Transplant, 2007 Aug. PMID 17617869

    See all (250) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci.
      Title: Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci.
    2. Complement regulatory protein CD46 promotes bladder cancer metastasis through activation of MMP9.
      Title: Complement regulatory protein CD46 promotes bladder cancer metastasis through activation of MMP9.
    3. Computational Analysis of CD46 Protein Interaction with SARS-CoV-2 Structural Proteins: Elucidating a Putative Viral Entry Mechanism into Human Cells.
      Title: Computational Analysis of CD46 Protein Interaction with SARS-CoV-2 Structural Proteins: Elucidating a Putative Viral Entry Mechanism into Human Cells.
    4. Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.
      Title: Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.
    5. Immunologic and Genetic Contributors to CD46-Dependent Immune Dysregulation.
      Title: Immunologic and Genetic Contributors to CD46-Dependent Immune Dysregulation.
    6. The association between CD46 expression in B cells and the pathogenesis of airway allergy.
      Title: The association between CD46 expression in B cells and the pathogenesis of airway allergy.
    7. The CD46 ectodomain participates in human cytomegalovirus infection of epithelial cells.
      Title: The CD46 ectodomain participates in human cytomegalovirus infection of epithelial cells.
    8. CD46 protects the bladder cancer cells from cetuximab-mediated cytotoxicity.
      Title: CD46 protects the bladder cancer cells from cetuximab-mediated cytotoxicity.
    9. Genetic analysis of CFH and MCP in Egyptian patients with immune-complex proliferative glomerulonephritis.
      Title: Genetic analysis of CFH and MCP in Egyptian patients with immune-complex proliferative glomerulonephritis.
    10. [Silencing CD46 and DSG2 in host A549 cells inhibits entry of human adenovirus type 3 and type 7 and reduces interleukin-8 release].
      Title: [Silencing CD46 and DSG2 in host A549 cells inhibits entry of human adenovirus type 3 and type 7 and reduces interleukin-8 release].
    Submit: New GeneRIF Correction See all GeneRIFs (162)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Common variants associated with general and MMR vaccine-related febrile seizures.
    EBI GWAS Catalog
    Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
    EBI GWAS Catalog
    Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD46 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef downregulates the cell surface expression of CD46 PubMed
    Pr55(Gag) gag HIV-1 Gag associates with CD46 weakly in HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26544

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adaptive immune response IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-10 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of memory T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of regulatory T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transforming growth factor beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sequestering of extracellular ligand from receptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in inner acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    membrane cofactor protein
    Names
    CD46 antigen, complement regulatory protein
    CD46 molecule, complement regulatory protein
    antigen identified by monoclonal antibody TRA-2-10
    complement membrane cofactor protein
    measles virus receptor
    membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
    trophoblast leucocyte common antigen
    trophoblast leukocyte common antigen
    trophoblast-lymphocyte cross-reactive antigen

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009296.1 RefSeqGene

      Range
      4982..48460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_155

    mRNA and Protein(s)

    1. NM_002389.4 → NP_002380.3  membrane cofactor protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_002380.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AI589224, BC030594, DB078198, X59410
      Consensus CDS
      CCDS1485.1
      UniProtKB/Swiss-Prot
      A0T1T0, A0T1T1, A0T1T2, P15529, Q15429, Q53GV9, Q5HY94, Q5VWS6, Q5VWS7, Q5VWS8, Q5VWS9, Q5VWT0, Q5VWT1, Q5VWT2, Q6N0A1, Q7Z3R5, Q9NNW2, Q9NNW3, Q9NNW4, Q9UCJ4
      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Related
      ENSP00000350893.2, ENST00000358170.6
      Conserved Domains (2) summary
      cd00033
      Location:99 → 158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:35 → 88
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    2. NM_153826.4 → NP_722548.1  membrane cofactor protein isoform 4 precursor

      See identical proteins and their annotated locations for NP_722548.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) lacks an alternate in-frame exon and an exon containing the stop codon as compared to variant a. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC030594, DB078198
      Consensus CDS
      CCDS1480.1
      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Related
      ENSP00000346912.1, ENST00000354848.5
      Conserved Domains (2) summary
      cd00033
      Location:99 → 158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:35 → 88
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    3. NM_172350.3 → NP_758860.1  membrane cofactor protein isoform 14 precursor

      See identical proteins and their annotated locations for NP_758860.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (n) lacks three alternate in-frame exons as well as an alternate segment compared to variant a, which causes a frameshift. The resulting isoform (14) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC030594, D84105, DB078198
      Consensus CDS
      CCDS1479.1
      UniProtKB/TrEMBL
      A0A8Q3WLU6
      Related
      ENSP00000314664.5, ENST00000322918.9
      Conserved Domains (2) summary
      cd00033
      Location:99 → 158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:35 → 88
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    4. NM_172351.3 → NP_758861.1  membrane cofactor protein isoform 3 precursor

      See identical proteins and their annotated locations for NP_758861.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) lacks an alternate in-frame exon compared to variant a, resulting in a shorter isoform (3) compared to isoform 1.
      Source sequence(s)
      DB078198, X59405
      Consensus CDS
      CCDS31008.1
      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Related
      ENSP00000356009.1, ENST00000367042.6
      Conserved Domains (2) summary
      cd00033
      Location:99 → 158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:35 → 88
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    5. NM_172352.3 → NP_758862.1  membrane cofactor protein isoform 5 precursor

      See identical proteins and their annotated locations for NP_758862.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) lacks an alternate in-frame segment compared to variant a, resulting in a shorter isoform (5) compared to isoform 1.
      Source sequence(s)
      BC030594, DB078198, X59406
      Consensus CDS
      CCDS31009.1
      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Related
      ENSP00000356008.1, ENST00000367041.5
      Conserved Domains (2) summary
      cd00033
      Location:99 → 158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:35 → 88
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    6. NM_172353.3 → NP_758863.1  membrane cofactor protein isoform 6 precursor

      See identical proteins and their annotated locations for NP_758863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) lacks an alternate in-frame exon and an exon containing the stop codon compared to variant a. The resulting isoform (6) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC030594, DB078198, X59407
      Consensus CDS
      CCDS1481.1
      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Related
      ENSP00000350346.1, ENST00000357714.5
      Conserved Domains (2) summary
      cd00033
      Location:99 → 158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:35 → 88
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    7. NM_172355.3 → NP_758865.1  membrane cofactor protein isoform 9 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (i) lacks two alternate in-frame exons compared to variant a, resulting in a shorter isoform (9) compared to isoform 1.
      Source sequence(s)
      AL035209, AL365178
      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Conserved Domains (1) summary
      cl27761
      Location:54 → 285
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    8. NM_172356.3 → NP_758866.1  membrane cofactor protein isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AL035209, AL365178
      Consensus CDS
      CCDS86048.1
      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Related
      ENSP00000418471.1, ENST00000480003.5
      Conserved Domains (1) summary
      cl27761
      Location:54 → 285
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    9. NM_172357.3 → NP_758867.1  membrane cofactor protein isoform 11 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (k) lacks an alternate in-frame segment compared to variant a, resulting in a shorter isoform (11) compared to isoform 1.
      Source sequence(s)
      AL035209, AL365178
      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Related
      ENST00000695779.1
      Conserved Domains (1) summary
      cl27761
      Location:54 → 285
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    10. NM_172358.3 → NP_758868.1  membrane cofactor protein isoform 13 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (m) lacks an alternate in-frame exon, an alternate exon containing the stop codon, and an alternate segment compared to variant a, which causes a frameshift. The resulting isoform (13) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL035209, AL365178
      UniProtKB/TrEMBL
      A0A8Q3WLA6, A0A8Q3WLU6
      Related
      ENSP00000512167.1, ENST00000695777.1
      Conserved Domains (1) summary
      cl27761
      Location:54 → 285
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    11. NM_172359.3 → NP_758869.1  membrane cofactor protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_758869.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) lacks an alternate exon containing the stop codon compared to variant a. The resulting isoform (2) is longer and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK222822, BC030594, DB078198, X59410
      Consensus CDS
      CCDS1482.1
      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Related
      ENSP00000313875.4, ENST00000322875.8
      Conserved Domains (2) summary
      cd00033
      Location:99 → 158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:35 → 88
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    12. NM_172361.3 → NP_758871.1  membrane cofactor protein isoform 12 precursor

      See identical proteins and their annotated locations for NP_758871.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (l) lacks an alternate in-frame segment and an exon containing the stop codon as compared to variant a. The resulting isoform (12) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC030594, DB078198, EF076057
      Consensus CDS
      CCDS1484.1
      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Related
      ENSP00000353342.2, ENST00000360212.6
      Conserved Domains (2) summary
      cd00033
      Location:99 → 158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:35 → 88
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      207752038..207795516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509563.3 → XP_011507865.1  membrane cofactor protein isoform X2

      See identical proteins and their annotated locations for XP_011507865.1

      UniProtKB/TrEMBL
      A0A8Q3WKR0
      Conserved Domains (2) summary
      cd00033
      Location:99 → 158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:35 → 88
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    2. XM_047420888.1 → XP_047276844.1  membrane cofactor protein isoform X1

      UniProtKB/Swiss-Prot
      A0T1T0, A0T1T1, A0T1T2, P15529, Q15429, Q53GV9, Q5HY94, Q5VWS6, Q5VWS7, Q5VWS8, Q5VWS9, Q5VWT0, Q5VWT1, Q5VWT2, Q6N0A1, Q7Z3R5, Q9NNW2, Q9NNW3, Q9NNW4, Q9UCJ4
      UniProtKB/TrEMBL
      A0A8Q3WKR0

    3. XM_047420894.1 → XP_047276850.1  membrane cofactor protein isoform X3

      UniProtKB/TrEMBL
      A0A8Q3WKR0

    4. XM_047420901.1 → XP_047276857.1  membrane cofactor protein isoform X4

      UniProtKB/TrEMBL
      A0A8Q3WKR0

    5. XM_047420909.1 → XP_047276865.1  membrane cofactor protein isoform X5

      UniProtKB/TrEMBL
      A0A8Q3WKR0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      206998784..207042279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336646.1 → XP_054192621.1  membrane cofactor protein isoform X2

      UniProtKB/TrEMBL
      A0A8Q3WKR0

    2. XM_054336645.1 → XP_054192620.1  membrane cofactor protein isoform X1

      UniProtKB/Swiss-Prot
      A0T1T0, A0T1T1, A0T1T2, P15529, Q15429, Q53GV9, Q5HY94, Q5VWS6, Q5VWS7, Q5VWS8, Q5VWS9, Q5VWT0, Q5VWT1, Q5VWT2, Q6N0A1, Q7Z3R5, Q9NNW2, Q9NNW3, Q9NNW4, Q9UCJ4
      UniProtKB/TrEMBL
      A0A8Q3WKR0

    3. XM_054336647.1 → XP_054192622.1  membrane cofactor protein isoform X3

      UniProtKB/TrEMBL
      A0A8Q3WKR0

    4. XM_054336648.1 → XP_054192623.1  membrane cofactor protein isoform X4

      UniProtKB/TrEMBL
      A0A8Q3WKR0

    5. XM_054336649.1 → XP_054192624.1  membrane cofactor protein isoform X5

      UniProtKB/TrEMBL
      A0A8Q3WKR0

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172354.1: Suppressed sequence

      Description
      NM_172354.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_172360.1: Suppressed sequence

      Description
      NM_172360.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15529.3 GenPept UniProtKB/Swiss-Prot:P15529

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