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    ZMYND8 zinc finger MYND-type containing 8 [ Homo sapiens (human) ]

    Gene ID: 23613, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZMYND8provided by HGNC
    Official Full Name
    zinc finger MYND-type containing 8provided by HGNC
    Primary source
    HGNC:HGNC:9397
    See related
    Ensembl:ENSG00000101040 MIM:615713; AllianceGenome:HGNC:9397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RACK7; PRKCBP1; PRO2893
    Summary
    The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 6.9), testis (RPKM 4.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZMYND8 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (47209214..47356699, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (48947314..49094980, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45837859..45985443, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene EYA transcriptional coactivator and phosphatase 2 Neighboring gene Sharpr-MPRA regulatory region 12423 Neighboring gene ribosomal protein S2 pseudogene 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17980 Neighboring gene Sharpr-MPRA regulatory region 5760 Neighboring gene microRNA 3616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45836841-45837466 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45837467-45838090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45863077-45863577 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45881941-45882441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45904588-45905088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45905089-45905589 Neighboring gene Sharpr-MPRA regulatory region 15539 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:45945484-45946683 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45947067-45947983 Neighboring gene uncharacterized LOC100131496 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45947984-45948902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45950739-45951656 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45957753-45958400 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45959988-45960488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45964446-45965285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45965286-45966124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45968129-45968628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45971039-45971820 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45974595-45975341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17984 Neighboring gene uncharacterized LOC101927377 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45983444-45984051 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45985267-45985874 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45986483-45987088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr20:45987089-45987696 and GRCh37_chr20:45987697-45988304 Neighboring gene CRISPRi-validated cis-regulatory element chr20.2033 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46001472-46002090 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46004693-46005194 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46005195-46005694 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46007335-46007835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46012139-46012991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17989 Neighboring gene long intergenic non-protein coding RNA 1754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46044799-46045298 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46057414-46057914 Neighboring gene MPRA-validated peak4230 silencer Neighboring gene MPRA-validated peak4231 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17995 Neighboring gene Sharpr-MPRA regulatory region 10107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17996 Neighboring gene ribosomal protein L35a pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (227 hits/1293 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC31836

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding  
    enables lysine-acetylated histone binding PubMed 
    enables methylated histone binding PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables transcription corepressor activity  
    enables transcription corepressor activity PubMed 
    enables transcription corepressor activity  
    enables zinc ion binding PubMed 
    Component Evidence Code Pubs
    located_in chromatin PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in dendritic shaft  
    located_in dendritic spine  
    located_in nucleolus  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in site of DNA damage PubMed 

    General protein information

    Preferred Names
    MYND-type zinc finger-containing chromatin reader ZMYND8
    Names
    CTCL tumor antigen se14-3
    RACK like clone 7
    cutaneous T-cell lymphoma-associated antigen se14-3
    predicted protein of HQ2893
    protein kinase C-binding protein 1
    transcription coregulator ZMYND8
    zinc finger MYND domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281769.2 → NP_001268698.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform d

      See identical proteins and their annotated locations for NP_001268698.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (d) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BC092432, BX095755
      UniProtKB/TrEMBL
      Q569J9
      Conserved Domains (1) summary
      cd15538
      Location:110 → 150
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    2. NM_001281771.3 → NP_001268700.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform e

      See identical proteins and their annotated locations for NP_001268700.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC136608, BC146802, DQ368671, DR422399
      Consensus CDS
      CCDS63304.1
      UniProtKB/TrEMBL
      A0A087WYS3
      Related
      ENSP00000392964.2, ENST00000458360.6
      Conserved Domains (7) summary
      cd05841
      Location:264 → 344
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:146 → 244
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:85 → 125
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:896 → 930
      zf-MYND; MYND finger
      pfam07798
      Location:801 → 892
      DUF1640; Protein of unknown function (DUF1640)
      pfam10243
      Location:599 → 892
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam12064
      Location:421 → 615
      DUF3544; Domain of unknown function (DUF3544)
    3. NM_001281772.3 → NP_001268701.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, has multiple coding region differences, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (f) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AB032951, AI275390, AK294511, AL022342, BC146802, DQ368674, DR422399
      Consensus CDS
      CCDS74738.1
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000379577.4, ENST00000396281.8
      Conserved Domains (6) summary
      cd05841
      Location:269 → 349
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:151 → 249
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:90 → 130
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:1028 → 1062
      zf-MYND; MYND finger
      pfam07798
      Location:933 → 1024
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:426 → 620
      DUF3544; Domain of unknown function (DUF3544)
    4. NM_001281773.3 → NP_001268702.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform g

      See identical proteins and their annotated locations for NP_001268702.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in its 5' UTR, uses an alternate in-frame splice site in the central coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (g) is longer, compared to isoform a.
      Source sequence(s)
      AI275390, AK299899, AL022342, BC146802, DR422399
      Consensus CDS
      CCDS63300.1
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000348246.4, ENST00000355972.8
      Conserved Domains (6) summary
      cd05841
      Location:269 → 349
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:151 → 249
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:90 → 130
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:1028 → 1062
      zf-MYND; MYND finger
      pfam07798
      Location:933 → 1024
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:426 → 620
      DUF3544; Domain of unknown function (DUF3544)
    5. NM_001281774.3 → NP_001268703.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform h

      See identical proteins and their annotated locations for NP_001268703.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in its 5' UTR, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, BX641005, DQ368669, DR422399
      Consensus CDS
      CCDS63301.1
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000262975.4, ENST00000262975.8
      Conserved Domains (6) summary
      cd05841
      Location:269 → 349
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:151 → 249
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:90 → 130
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:982 → 1016
      zf-MYND; MYND finger
      pfam07798
      Location:887 → 978
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:426 → 620
      DUF3544; Domain of unknown function (DUF3544)
    6. NM_001281775.3 → NP_001268704.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform i

      See identical proteins and their annotated locations for NP_001268704.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (i) is longer, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368673, DR422399
      Consensus CDS
      CCDS63306.1
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000420095.2, ENST00000471951.7
      Conserved Domains (6) summary
      cd05841
      Location:289 → 369
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:171 → 269
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:110 → 150
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:1048 → 1082
      zf-MYND; MYND finger
      pfam07798
      Location:953 → 1044
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:446 → 640
      DUF3544; Domain of unknown function (DUF3544)
    7. NM_001281776.3 → NP_001268705.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform j

      See identical proteins and their annotated locations for NP_001268705.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (j) is shorter, compared to isoform a.
      Source sequence(s)
      AI275390, AK299899, AL022342, BC146802, DC362133, DQ082999, DR422399
      UniProtKB/TrEMBL
      A0A087WYS3
      Related
      ENSP00000482048.1, ENST00000611941.4
      Conserved Domains (7) summary
      cd05841
      Location:289 → 369
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:171 → 269
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:110 → 150
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:921 → 955
      zf-MYND; MYND finger
      pfam07798
      Location:826 → 917
      DUF1640; Protein of unknown function (DUF1640)
      pfam10243
      Location:624 → 917
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam12064
      Location:446 → 640
      DUF3544; Domain of unknown function (DUF3544)
    8. NM_001281777.3 → NP_001268706.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform k

      See identical proteins and their annotated locations for NP_001268706.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (k) is shorter, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368672, DR422399
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000361093.5, ENST00000372023.7
      Conserved Domains (6) summary
      cd05841
      Location:264 → 344
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:146 → 244
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:85 → 125
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:977 → 1011
      zf-MYND; MYND finger
      pfam07798
      Location:882 → 973
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:421 → 615
      DUF3544; Domain of unknown function (DUF3544)
    9. NM_001281778.3 → NP_001268707.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform l

      See identical proteins and their annotated locations for NP_001268707.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (l) is shorter, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368674, DR422399
      UniProtKB/TrEMBL
      H7C4X9
      Conserved Domains (6) summary
      cd05841
      Location:264 → 344
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:146 → 244
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:85 → 125
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:1023 → 1057
      zf-MYND; MYND finger
      pfam07798
      Location:928 → 1019
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:421 → 615
      DUF3544; Domain of unknown function (DUF3544)
    10. NM_001281779.3 → NP_001268708.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (m) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368675, DR422399
      UniProtKB/TrEMBL
      H7C4X9
      Conserved Domains (4) summary
      cd05841
      Location:21 → 101
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      pfam01753
      Location:734 → 768
      zf-MYND; MYND finger
      pfam07798
      Location:639 → 730
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:178 → 372
      DUF3544; Domain of unknown function (DUF3544)
    11. NM_001281780.3 → NP_001268709.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform n

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in its 5' UTR, lacks an in-frame exon in the 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (n) is shorter, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368676, DR422399
      UniProtKB/TrEMBL
      H7C4X9
      Conserved Domains (4) summary
      cd05841
      Location:21 → 101
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      pfam01753
      Location:734 → 768
      zf-MYND; MYND finger
      pfam07798
      Location:639 → 730
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:178 → 372
      DUF3544; Domain of unknown function (DUF3544)
    12. NM_001281781.3 → NP_001268710.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform o

      See identical proteins and their annotated locations for NP_001268710.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (o) is shorter, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368677, DR422399
      UniProtKB/TrEMBL
      H7C4X9
      Conserved Domains (6) summary
      cd05841
      Location:264 → 344
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:146 → 244
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:85 → 125
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:930 → 964
      zf-MYND; MYND finger
      pfam07798
      Location:835 → 926
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:421 → 568
      DUF3544; Domain of unknown function (DUF3544)
    13. NM_001281782.3 → NP_001268711.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform p

      See identical proteins and their annotated locations for NP_001268711.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) uses an alternate in-frame splice site and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (p) is shorter, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368678, DR422399
      Consensus CDS
      CCDS63305.1
      UniProtKB/TrEMBL
      A0A087WVZ6, H7C4X9
      Related
      ENSP00000479806.2, ENST00000617418.4
      Conserved Domains (6) summary
      cd05841
      Location:264 → 344
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:146 → 244
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:85 → 125
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:950 → 984
      zf-MYND; MYND finger
      pfam11068
      Location:875 → 939
      YlqD; YlqD protein
      pfam12064
      Location:421 → 615
      DUF3544; Domain of unknown function (DUF3544)
    14. NM_001281783.3 → NP_001268712.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform q

      See identical proteins and their annotated locations for NP_001268712.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) uses an alternate in-frame splice site in the central coding region and lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (q) is longer, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368679, DR422399
      UniProtKB/TrEMBL
      H7C4X9
      Conserved Domains (6) summary
      cd05841
      Location:289 → 369
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:171 → 269
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:110 → 150
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:1048 → 1082
      zf-MYND; MYND finger
      pfam07798
      Location:953 → 1044
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:446 → 640
      DUF3544; Domain of unknown function (DUF3544)
    15. NM_001281784.3 → NP_001268713.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform r

      See identical proteins and their annotated locations for NP_001268713.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (r) is shorter, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368680, DR422399
      Consensus CDS
      CCDS63303.1
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000443086.3, ENST00000540497.5
      Conserved Domains (6) summary
      cd05841
      Location:264 → 344
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:146 → 244
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:85 → 125
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:976 → 1010
      zf-MYND; MYND finger
      pfam07798
      Location:881 → 972
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:421 → 568
      DUF3544; Domain of unknown function (DUF3544)
    16. NM_001363714.1 → NP_001350643.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform s

      Status: REVIEWED

      Source sequence(s)
      AK295747, AL022342, AL031666
      Consensus CDS
      CCDS86962.1
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000439800.1, ENST00000536340.5
      Conserved Domains (8) summary
      cd05841
      Location:296 → 376
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:178 → 276
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:117 → 157
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:1055 → 1089
      zf-MYND; MYND finger
      pfam07798
      Location:960 → 1051
      DUF1640; Protein of unknown function (DUF1640)
      pfam10243
      Location:634 → 795
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam12064
      Location:445 → 647
      DUF3544; Domain of unknown function (DUF3544)
      cl26267
      Location:31 → 160
      ING; Inhibitor of growth proteins N-terminal histone-binding
    17. NM_001363741.2 → NP_001350670.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform t

      Status: REVIEWED

      Source sequence(s)
      AL022342, AL031666
      Consensus CDS
      CCDS86961.1
      UniProtKB/Swiss-Prot
      B3KVL2, B7Z2A8, B7Z3E0, B7Z680, B7ZM62, E1P5U5, F5H0X3, H7C0U2, J3KPU3, Q13517, Q2HXV1, Q2HXV2, Q2HXV3, Q2HXV4, Q2HXV7, Q2HXV8, Q2HXV9, Q2HXW0, Q2HXW1, Q2HXW2, Q4JJ94, Q4JJ95, Q5TH09, Q5TH11, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6, Q9ULU4
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000312237.7, ENST00000311275.11
      Conserved Domains (8) summary
      cd05841
      Location:269 → 349
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:151 → 249
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:90 → 130
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:1028 → 1062
      zf-MYND; MYND finger
      pfam07798
      Location:933 → 1024
      DUF1640; Protein of unknown function (DUF1640)
      pfam10243
      Location:607 → 768
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam12064
      Location:418 → 620
      DUF3544; Domain of unknown function (DUF3544)
      cl26267
      Location:4 → 133
      ING; Inhibitor of growth proteins N-terminal histone-binding
    18. NM_012408.6 → NP_036540.3  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform b

      See identical proteins and their annotated locations for NP_036540.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368670, DR422399
      Consensus CDS
      CCDS13404.1
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000335537.3, ENST00000352431.6
      Conserved Domains (6) summary
      cd05841
      Location:289 → 369
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:171 → 269
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:110 → 150
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:1002 → 1036
      zf-MYND; MYND finger
      pfam07798
      Location:907 → 998
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:446 → 640
      DUF3544; Domain of unknown function (DUF3544)
    19. NM_183047.4 → NP_898868.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform a

      See identical proteins and their annotated locations for NP_898868.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368669, DR422399
      Consensus CDS
      CCDS13405.1
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000418210.1, ENST00000461685.5
      Conserved Domains (6) summary
      cd05841
      Location:289 → 369
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:171 → 269
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:110 → 150
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:1002 → 1036
      zf-MYND; MYND finger
      pfam07798
      Location:907 → 998
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:446 → 640
      DUF3544; Domain of unknown function (DUF3544)
    20. NM_183048.4 → NP_898869.1  MYND-type zinc finger-containing chromatin reader ZMYND8 isoform c

      See identical proteins and their annotated locations for NP_898869.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AI275390, AL022342, BC146802, DC362133, DQ368671, DR422399
      Consensus CDS
      CCDS46613.1
      UniProtKB/TrEMBL
      H7C4X9
      Related
      ENSP00000354166.3, ENST00000360911.7
      Conserved Domains (6) summary
      cd05841
      Location:264 → 344
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05508
      Location:146 → 244
      Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
      cd15538
      Location:85 → 125
      PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
      pfam01753
      Location:977 → 1011
      zf-MYND; MYND finger
      pfam07798
      Location:882 → 973
      DUF1640; Protein of unknown function (DUF1640)
      pfam12064
      Location:421 → 615
      DUF3544; Domain of unknown function (DUF3544)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      47209214..47356699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      48947314..49094980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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