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    MRPS5 mitochondrial ribosomal protein S5 [ Homo sapiens (human) ]

    Gene ID: 64969, updated on 10-Dec-2024

    Summary

    Official Symbol
    MRPS5provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S5provided by HGNC
    Primary source
    HGNC:HGNC:14498
    See related
    Ensembl:ENSG00000144029 MIM:611972; AllianceGenome:HGNC:14498
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S5mt; uS5m; MRP-S5
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 9.5), duodenum (RPKM 9.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MRPS5 in Genome Data Viewer
    Location:
    2q11.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (95085369..95122003, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95591870..95628506, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95751114..95787748, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene mal, T cell differentiation protein Neighboring gene uncharacterized LOC124906047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95713447-95713986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16181 Neighboring gene uncharacterized LOC124907857 Neighboring gene uncharacterized LOC105373488 Neighboring gene NANOG hESC enhancer GRCh37_chr2:95753198-95753763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11739 Neighboring gene zinc finger protein 514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:95830542-95831178 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:95831179-95831813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95843643-95844143 Neighboring gene zinc finger protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in mitochondrial translation PubMed 
    involved_in translation  

    General protein information

    Preferred Names
    small ribosomal subunit protein uS5m
    Names
    28S ribosomal protein S5, mitochondrial
    mitochondrial 28S ribosomal protein S5
    mitochondrial small ribosomal subunit protein uS5m

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321995.2 → NP_001308924.1  small ribosomal subunit protein uS5m isoform b

      Status: REVIEWED

      Source sequence(s)
      AC092835
      Consensus CDS
      CCDS92806.1
      UniProtKB/TrEMBL
      A0A8Q3SIP9, A0A8Q3WKG3
      Related
      ENSP00000511925.1, ENST00000695434.1
      Conserved Domains (3) summary
      TIGR01021
      Location:138 → 293
      rpsE_bact; ribosomal protein S5, bacterial/organelle type
      pfam00333
      Location:139 → 204
      Ribosomal_S5; Ribosomal protein S5, N-terminal domain
      pfam03719
      Location:218 → 286
      Ribosomal_S5_C; Ribosomal protein S5, C-terminal domain
    2. NM_001321996.2 → NP_001308925.1  small ribosomal subunit protein uS5m isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), along with variant 4, encodes isoform c.
      Source sequence(s)
      AC092835
      Conserved Domains (3) summary
      COG0098
      Location:26 → 207
      RpsE; Ribosomal protein S5 [Translation, ribosomal structure and biogenesis]
      pfam00333
      Location:52 → 117
      Ribosomal_S5; Ribosomal protein S5, N-terminal domain
      pfam03719
      Location:131 → 199
      Ribosomal_S5_C; Ribosomal protein S5, C-terminal domain
    3. NM_001321997.2 → NP_001308926.1  small ribosomal subunit protein uS5m isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), along with variant 3, encodes isoform c.
      Source sequence(s)
      AC092835
      Conserved Domains (3) summary
      COG0098
      Location:26 → 207
      RpsE; Ribosomal protein S5 [Translation, ribosomal structure and biogenesis]
      pfam00333
      Location:52 → 117
      Ribosomal_S5; Ribosomal protein S5, N-terminal domain
      pfam03719
      Location:131 → 199
      Ribosomal_S5_C; Ribosomal protein S5, C-terminal domain
    4. NM_031902.5 → NP_114108.1  small ribosomal subunit protein uS5m isoform a

      See identical proteins and their annotated locations for NP_114108.1

      Status: REVIEWED

      Source sequence(s)
      AC092835
      Consensus CDS
      CCDS2010.1
      UniProtKB/Swiss-Prot
      P82675, Q4ZFY5, Q96LJ6, Q9BWI4, Q9BYC4
      UniProtKB/TrEMBL
      A0A8Q3WKG3
      Related
      ENSP00000272418.2, ENST00000272418.7
      Conserved Domains (1) summary
      COG0098
      Location:221 → 373
      RpsE; Ribosomal protein S5 [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_136152.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC092835
      Related
      ENST00000695437.2
    2. NR_136153.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC092835
      Related
      ENST00000345084.11

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      95085369..95122003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      95591870..95628506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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