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    FOXD2-AS1 FOXD2 adjacent opposite strand RNA 1 [ Homo sapiens (human) ]

    Gene ID: 84793, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FOXD2-AS1provided by HGNC
    Official Full Name
    FOXD2 adjacent opposite strand RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:44256
    See related
    Ensembl:ENSG00000237424 AllianceGenome:HGNC:44256
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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    Genomic context

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    See FOXD2-AS1 in Genome Data Viewer
    Location:
    1p33
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (47432133..47434641, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (47310585..47313093, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47897805..47900313, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:47799401-47800204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47800205-47801008 Neighboring gene cytidine/uridine monophosphate kinase 1 Neighboring gene long intergenic non-protein coding RNA 1389 Neighboring gene Sharpr-MPRA regulatory region 7712 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_8190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 855 Neighboring gene forkhead box E3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47899798-47900313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47905134-47905903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47911867-47912367 Neighboring gene forkhead box D2 Neighboring gene ribosomal protein L21 pseudogene 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNA FOXD2-AS1 aggravates hepatocellular carcinoma tumorigenesis by regulating the miR-206/MAP3K1 axis. Hu W, et al. Cancer Med, 2020 Aug. PMID 32558350, Free PMC Article
    2. FOXD2-AS1 correlates with the malignant status and regulates cell proliferation, migration, and invasion in cutaneous melanoma. Ren W, et al. J Cell Biochem, 2019 Apr. PMID 30426532
    3. Oncogenicity of lncRNA FOXD2-AS1 and its molecular mechanisms in human cancers. Hu Q, et al. Pathol Res Pract, 2019 May. PMID 30723052
    4. Downregulation of the long non‑coding RNA FOXD2‑AS1 inhibits cell proliferation, migration and invasion in osteosarcoma. Zhang H, et al. Mol Med Rep, 2019 Jul. PMID 31115575, Free PMC Article
    5. [FOXD2-AS1 is corelated with clinicopathological parameter of laryngeal carcinoma and promote cancer cell proliferation]. Chen W, et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2019 May. PMID 31163553

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOXD2-AS1 promotes malignant cell behavior in oral squamous cell carcinoma via the miR-378 g/CRABP2 axis.
      Title: FOXD2-AS1 promotes malignant cell behavior in oral squamous cell carcinoma via the miR-378 g/CRABP2 axis.
    2. LncRNA FOXD2-AS1 promotes the growth, invasion and migration of OSCC cells by regulating the MiR-185-5p/PLOD1/Akt/mTOR pathway.
      Title: LncRNA FOXD2-AS1 promotes the growth, invasion and migration of OSCC cells by regulating the MiR-185-5p/PLOD1/Akt/mTOR pathway.
    3. A review on the role of FOXD2-AS1 in human disorders.
      Title: A review on the role of FOXD2-AS1 in human disorders.
    4. LncRNA FOXD2-AS1 facilitates the progression of hepatocellular carcinoma by regulating TWIST1.
      Title: LncRNA FOXD2-AS1 facilitates the progression of hepatocellular carcinoma by regulating TWIST1.
    5. Highly-expressed lncRNA FOXD2-AS1 in adipose mesenchymal stem cell derived exosomes affects HaCaT cells via regulating miR-185-5p/ROCK2 axis.
      Title: Highly-expressed lncRNA FOXD2-AS1 in adipose mesenchymal stem cell derived exosomes affects HaCaT cells via regulating miR-185-5p/ROCK2 axis.
    6. Identification and Validation of Cuproptosis-Related LncRNA Signatures in the Prognosis and Immunotherapy of Clear Cell Renal Cell Carcinoma Using Machine Learning.
      Title: Identification and Validation of Cuproptosis-Related LncRNA Signatures in the Prognosis and Immunotherapy of Clear Cell Renal Cell Carcinoma Using Machine Learning.
    7. FOXD2-AS1 acts an oncogene in esophageal squamous cell carcinoma through sponging miR-204-3p.
      Title: FOXD2-AS1 acts an oncogene in esophageal squamous cell carcinoma through sponging miR-204-3p.
    8. Moderate Prognostic Value of lncRNA FOXD2-AS1 in Gastric Cancer with Helicobacter pylori Infection.
      Title: Moderate Prognostic Value of lncRNA FOXD2-AS1 in Gastric Cancer with Helicobacter pylori Infection.
    9. Overexpression of FOXD2-AS1 enhances proliferation and impairs differentiation of glioma stem cells by activating the NOTCH pathway via TAF-1.
      Title: Overexpression of FOXD2-AS1 enhances proliferation and impairs differentiation of glioma stem cells by activating the NOTCH pathway via TAF-1.
    10. Long Noncoding RNA FOXD2-AS1 Promotes Pancreas Adenocarcinoma Cell Invasion and Migration by Sponging miR-30a-3p to Upregulate COX-2.
      Title: Long Noncoding RNA FOXD2-AS1 Promotes Pancreas Adenocarcinoma Cell Invasion and Migration by Sponging miR-30a-3p to Upregulate COX-2.
    Submit: New GeneRIF Correction See all GeneRIFs (48)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • FOXD2 antisense RNA 1 (head to head)
    • FOXD2 antisense RNA 1 (non-protein coding)

    Clone Names

    • MGC12982

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026878.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL607122, BC006113
      Related
      ENST00000445551.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      47432133..47434641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      47310585..47313093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032707.1: Suppressed sequence

      Description
      NM_032707.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials