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    LINGO2 leucine rich repeat and Ig domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 158038, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINGO2provided by HGNC
    Official Full Name
    leucine rich repeat and Ig domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:21207
    See related
    Ensembl:ENSG00000174482 MIM:609793; AllianceGenome:HGNC:21207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LERN3; LRRN6C
    Summary
    Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in several cellular components, including extracellular space; glutamatergic synapse; and synaptic membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See LINGO2 in Genome Data Viewer
    Location:
    9p21.2-p21.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (27937617..29213601, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (27948210..29231596, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (27937615..29213599, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376002 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:27679142-27679886 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:27683189-27684388 Neighboring gene uncharacterized LOC124902135 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_107363 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:27771740-27772389 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27788871-27789372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19823 Neighboring gene putative UPF0607 protein ENSP00000383783 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr9:28317701-28318202 Neighboring gene NANOG hESC enhancer GRCh37_chr9:28389345-28389846 Neighboring gene uncharacterized LOC105376004 Neighboring gene uncharacterized LOC124902136 Neighboring gene uncharacterized LOC105376003 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:28688087-28688762 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_107568 Neighboring gene potassium channel tetramerization domain containing 10 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:28775137-28775636 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:28820708-28821279 Neighboring gene NANOG hESC enhancer GRCh37_chr9:28929045-28929614 Neighboring gene NANOG hESC enhancer GRCh37_chr9:28938893-28939474 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:28970143-28971066 Neighboring gene microRNA 876 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_107603 Neighboring gene microRNA 873 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_107631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19824 Neighboring gene NANOG hESC enhancer GRCh37_chr9:29251246-29251747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28256 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:29439922-29441121 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:29450054-29451253 Neighboring gene pyruvate dehydrogenase kinase 1 pseudogene 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:29566267-29567466 Neighboring gene uncharacterized LOC105376005

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lingo2 variants associated with essential tremor and Parkinson's disease. Wu YW, et al. Hum Genet, 2011 Jun. PMID 21287203
    2. Novel Gastric Cancer Stem Cell-Related Marker LINGO2 Is Associated with Cancer Cell Phenotype and Patient Outcome. Jo JH, et al. Int J Mol Sci, 2019 Jan 28. PMID 30696080, Free PMC Article
    3. A genetic variant in LINGO2 contributes to the risk of gestational diabetes mellitus in a Chinese population. Su T, et al. J Cell Physiol, 2019 May. PMID 30426492
    4. Association of the LINGO2-related SNP rs10968576 with body mass in a cohort of elderly Swedes. Rask-Andersen M, et al. Mol Genet Genomics, 2015 Aug. PMID 25711307
    5. LINGO-2 polymorphism and the risk of Parkinson's disease in Taiwan. Su FC, et al. Parkinsonism Relat Disord, 2012 Jun. PMID 22123311

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Variations in the LINGO2 and GLIS3 Genes and Gene-Environment Interactions Increase Gestational Diabetes Mellitus Risk in Chinese Women.
      Title: Variations in the LINGO2 and GLIS3 Genes and Gene-Environment Interactions Increase Gestational Diabetes Mellitus Risk in Chinese Women.
    2. LINGO2 rs824248 may serve as a susceptibility marker for gestational diabetes mellitus in Chinese females.
      Title: A genetic variant in LINGO2 contributes to the risk of gestational diabetes mellitus in a Chinese population.
    3. These indicate the involvement of LINGO2 in gastric cancer initiation and progression by altering cell motility, stemness, and tumorigenicity.
      Title: Novel Gastric Cancer Stem Cell-Related Marker LINGO2 Is Associated with Cancer Cell Phenotype and Patient Outcome.
    4. Data indicate that rs10968576, an intronic single nucleotide polymorphism (SNP) within the leucine rich repeat and Ig domain containing 2 LINGO2 (LERN3, LRRN6C) gene was associated with body mass in elderly Swedes at age 70.
      Title: Association of the LINGO2-related SNP rs10968576 with body mass in a cohort of elderly Swedes.
    5. The results of this study concluded that the LINGO-2 variant rs109668280 does not contribute to the risk of developing parkinson disreas in Taiwan.
      Title: LINGO-2 polymorphism and the risk of Parkinson's disease in Taiwan.
    6. demonstrated for the first time that rs7033345 is associated with PD and ET and rs10812774 with ET among Asians, suggesting that LINGO2 might act as a susceptibility gene for essential tremor and Parkinson's disease
      Title: Lingo2 variants associated with essential tremor and Parkinson's disease.
    7. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease
      Title: LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
    EBI GWAS Catalog
    Genome-wide association study of endometrial cancer in E2C2.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31810

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2
    Names
    leucine rich repeat neuronal 6C
    leucine-rich repeat neuronal protein 3
    leucine-rich repeat neuronal protein 6C

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258282.3 → NP_001245211.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor

      See identical proteins and their annotated locations for NP_001245211.1

      Status: VALIDATED

      Source sequence(s)
      AL158072, AL162388, AL353683, AL353746, AL592206, AL596323, BX538226
      Consensus CDS
      CCDS6524.1
      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Related
      ENSP00000513694.1, ENST00000698399.1
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    2. NM_001354574.2 → NP_001341503.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL158072, AL162388, AL353683, AL353746, AL592206, AL596323, BX538226
      Consensus CDS
      CCDS6524.1
      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    3. NM_001354575.2 → NP_001341504.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL158072, AL162388, AL353683, AL353746, AL592206, AL596323, BX538226
      Consensus CDS
      CCDS6524.1
      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    4. NM_152570.4 → NP_689783.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor

      See identical proteins and their annotated locations for NP_689783.1

      Status: VALIDATED

      Source sequence(s)
      AL353683, AL353746, AL450428, AL592206, AL596323, BX538226
      Consensus CDS
      CCDS6524.1
      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Related
      ENSP00000369328.1, ENST00000379992.6
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      27937617..29213601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422814.1 → XP_047278770.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    2. XM_047422810.1 → XP_047278766.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    3. XM_017014303.3 → XP_016869792.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    4. XM_047422812.1 → XP_047278768.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    5. XM_047422818.1 → XP_047278774.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Related
      ENSP00000513696.1, ENST00000698401.1

    6. XM_047422815.1 → XP_047278771.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    7. XM_047422811.1 → XP_047278767.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    8. XM_047422813.1 → XP_047278769.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    9. XM_047422816.1 → XP_047278772.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    10. XM_047422817.1 → XP_047278773.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Related
      ENSP00000513695.1, ENST00000698400.1

    11. XM_011517728.3 → XP_011516030.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011516030.1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    12. XM_011517724.3 → XP_011516026.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011516026.1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    13. XM_017014305.2 → XP_016869794.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    14. XM_017014304.2 → XP_016869793.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    15. XM_017014306.3 → XP_016869795.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    16. XM_017014307.2 → XP_016869796.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0
      Conserved Domains (6) summary
      TIGR00864
      Location:327 → 391
      PCC; polycystin cation channel protein
      smart00013
      Location:27 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam07679
      Location:410 → 500
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:83 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:106 → 165
      LRR_8; Leucine rich repeat
      cl26222
      Location:146 → 276
      LRR_5; Leucine rich repeats (6 copies)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      27948210..29231596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362036.1 → XP_054218011.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    2. XM_054362030.1 → XP_054218005.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    3. XM_054362037.1 → XP_054218012.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    4. XM_054362032.1 → XP_054218007.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    5. XM_054362040.1 → XP_054218015.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    6. XM_054362033.1 → XP_054218008.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    7. XM_054362045.1 → XP_054218020.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    8. XM_054362031.1 → XP_054218006.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    9. XM_054362039.1 → XP_054218014.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    10. XM_054362034.1 → XP_054218009.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    11. XM_054362035.1 → XP_054218010.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    12. XM_054362038.1 → XP_054218013.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    13. XM_054362042.1 → XP_054218017.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    14. XM_054362044.1 → XP_054218019.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    15. XM_054362041.1 → XP_054218016.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    16. XM_054362043.1 → XP_054218018.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    17. XM_054362050.1 → XP_054218025.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    18. XM_054362049.1 → XP_054218024.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    19. XM_054362047.1 → XP_054218022.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    20. XM_054362046.1 → XP_054218021.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    21. XM_054362048.1 → XP_054218023.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    22. XM_054362051.1 → XP_054218026.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K4K7, B2RPM5, Q6ZMD0, Q7L985
      UniProtKB/TrEMBL
      B7ZMN0

    RNA

    1. XR_008487942.1 RNA Sequence

    2. XR_007080249.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L985.1 GenPept UniProtKB/Swiss-Prot:Q7L985

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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