Replication interactions
Interaction |
Pubs |
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SERINC3 |
PubMed
|
HIV-1 Nef deleted virus replication is restricted by SERINC3 and SERINC5 (combined effect of SERINC3 and SERINC5 noted) |
PubMed
|
HIV-1 Nef deleted virus is restricted by SERINC3; CRISPR-Cas9 knockout of SERINC3 in cells producing HIV-1 Nef deleted virus enhances infectivity HIV-1 Nef deleted virus of subsequent target cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Nef
|
nef
|
HIV-1 Nef counteracts restriction of HIV-1 replication by SERINC3 and SERINC5 |
PubMed
|
|
nef
|
HIV-1 Nef downregulates SERINC3 expression on the cell surfacem, which in turn, prevents incorporation into virions to an extent that correlates with infectivity enhancement |
PubMed
|
|
nef
|
HIV-1 Nef downregulates cell (CEMT4) surface expression of SERINC3 |
PubMed
|
Go to the HIV-1, Human Interaction Database