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    ZNF22 zinc finger protein 22 [ Homo sapiens (human) ]

    Gene ID: 7570, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF22provided by HGNC
    Official Full Name
    zinc finger protein 22provided by HGNC
    Primary source
    HGNC:HGNC:13012
    See related
    Ensembl:ENSG00000165512 MIM:194529; AllianceGenome:HGNC:13012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX15; HKR-T1; ZNF422; Zfp422
    Summary
    Predicted to enable DNA binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 19.3), lymph node (RPKM 18.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF22 in Genome Data Viewer
    Location:
    10q11.21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (45000923..45005326)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (45881879..45886287)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45496371..45500774)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Ras association domain family member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45470934-45471637 Neighboring gene Sharpr-MPRA regulatory region 8316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45475153-45475856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45475857-45476558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45479350-45479850 Neighboring gene DEPP autophagy regulator 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45486450-45487141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45487171-45487672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45487673-45488172 Neighboring gene uncharacterized LOC124902530 Neighboring gene ZNF22 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:45496487-45496987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45510141-45510640 Neighboring gene double homeobox A pseudogene 4 Neighboring gene centrosomal protein 164 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines. Wu BY, et al. Blood, 1992 Nov 15. PMID 1421376
    2. The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). Gao Y, et al. J Dent Res, 2003 Dec. PMID 14630903
    3. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. Rousseau-Merck MF, et al. Genomics, 1992 Jul. PMID 1639412
    4. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article
    5. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in odontogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 22
    Names
    krox-26 protein
    zinc finger protein 22 (KOX 15)
    zinc finger protein KOX15
    zinc finger protein Krox-26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006963.5 → NP_008894.2  zinc finger protein 22

      See identical proteins and their annotated locations for NP_008894.2

      Status: VALIDATED

      Source sequence(s)
      AL353801, AU310379, BC041139
      Consensus CDS
      CCDS7211.1
      UniProtKB/Swiss-Prot
      P17026, Q5T741, Q96FM4
      Related
      ENSP00000298299.3, ENST00000298299.4
      Conserved Domains (2) summary
      COG5048
      Location:41 → 194
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      45000923..45005326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      45881879..45886287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17026.3 GenPept UniProtKB/Swiss-Prot:P17026

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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