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    Rian RNA imprinted and accumulated in nucleus [ Mus musculus (house mouse) ]

    Gene ID: 75745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rianprovided by MGI
    Official Full Name
    RNA imprinted and accumulated in nucleusprovided by MGI
    Primary source
    MGI:MGI:1922995
    See related
    AllianceGenome:MGI:1922995
    Gene type
    ncRNA
    RefSeq status
    PREDICTED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Meg8; 5530401N18Rik; C130089L09Rik
    Summary
    Involved in chromatin organization. Acts upstream of or within several processes, including epithelial to mesenchymal transition; negative regulation of Notch signaling pathway; and negative regulation of hepatic stellate cell activation. Located in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; gut; metanephros; and sensory organ. Orthologous to human MEG8 (maternally expressed 8, small nucleolar RNA host gene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 593.4), CNS E18 (RPKM 350.8) and 11 other tissues See more
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    Genomic context

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    See Rian in Genome Data Viewer
    Location:
    12 F1; 12 60.41 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (109570379..109628150)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (109603945..109661716)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene retrotransposon Gaglike 1 Neighboring gene microRNA 3071 Neighboring gene microRNA 432 Neighboring gene microRNA 136 Neighboring gene microRNA 1188 Neighboring gene microRNA 341 Neighboring gene microRNA 370 Neighboring gene STARR-seq mESC enhancer starr_33267 Neighboring gene predicted gene, 24564 Neighboring gene snoRNA AF357425 Neighboring gene snoRNA AF357426 Neighboring gene snoRNA DQ267100 Neighboring gene snoRNA AF357359 Neighboring gene snoRNA DQ267101 Neighboring gene predicted gene, 23508 Neighboring gene predicted gene, 57588 Neighboring gene predicted gene, 26922 Neighboring gene snoRNA DQ267102 Neighboring gene predicted gene, 25357 Neighboring gene predicted gene, 23347 Neighboring gene snoRNA AF357428

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9. Han J, et al. RNA Biol, 2014. PMID 25137067, Free PMC Article
    2. Induction of hepatocellular carcinoma by in vivo gene targeting. Wang PR, et al. Proc Natl Acad Sci U S A, 2012 Jul 10. PMID 22733778, Free PMC Article
    3. Expression of macro non-coding RNAs Meg8 and Irm in mouse embryonic development. Gu T, et al. Acta Histochem, 2012 Jul. PMID 21855964
    4. Overexpression of long non-coding RNA Rian attenuates cell apoptosis from cerebral ischemia-reperfusion injury via Rian/miR-144-3p/GATA3 signaling. Yao P, et al. Gene, 2020 May 5. PMID 32006596
    5. Expression of non-coding RNA AB063319 derived from Rian gene during mouse development. Gu T, et al. J Mol Histol, 2011 Apr. PMID 21305344

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Meg8-DMR as the Secondary Regulatory Region Regulates the Expression of MicroRNAs While It Does Not Affect Embryonic Development in Mice.
      Title: Meg8-DMR as the Secondary Regulatory Region Regulates the Expression of MicroRNAs While It Does Not Affect Embryonic Development in Mice.
    2. LncRNA MEG8 Attenuates Cerebral Ischemia After Ischemic Stroke Through Targeting miR-130a-5p/VEGFA Signaling.
      Title: LncRNA MEG8 Attenuates Cerebral Ischemia After Ischemic Stroke Through Targeting miR-130a-5p/VEGFA Signaling.
    3. LncRNA Rian ameliorates sevoflurane anesthesia-induced cognitive dysfunction through regulation of miR-143-3p/LIMK1 axis.
      Title: LncRNA Rian ameliorates sevoflurane anesthesia-induced cognitive dysfunction through regulation of miR-143-3p/LIMK1 axis.
    4. Hypermethylation and reduced expression of Gtl2, Rian and Mirg at the Dlk1-Dio3 imprinted locus as a marker for poor developmental potential of mouse embryonic stem cells.
      Title: Hypermethylation and reduced expression of Gtl2, Rian and Mirg at the Dlk1-Dio3 imprinted locus as a marker for poor developmental potential of mouse embryonic stem cells.
    5. Rian/miR-210-3p/Nfkb1 Feedback Loop Promotes Hypoxia-Induced Cell Apoptosis in Myocardial Infarction Through Deactivating the PI3K/Akt Signaling Pathway.
      Title: Rian/miR-210-3p/Nfkb1 Feedback Loop Promotes Hypoxia-Induced Cell Apoptosis in Myocardial Infarction Through Deactivating the PI3K/Akt Signaling Pathway.
    6. Meg8 suppresses hepatic stellate cells activation and hepatocyte epithelial-mesenchymal transition through inhibiting the Notch pathway.
      Title: LncRNA Meg8 suppresses activation of hepatic stellate cells and epithelial-mesenchymal transition of hepatocytes via the Notch pathway.
    7. findings showed that the Rian/miR-144-3p/GATA3 axis is an essential signaling in cerebral I/R injury. The lncRNA Rian may serve as a potential target for novel treatment in patients with ischemic stroke
      Title: Overexpression of long non-coding RNA Rian attenuates cell apoptosis from cerebral ischemia-reperfusion injury via Rian/miR-144-3p/GATA3 signaling.
    8. Authors addressed this question by generating transgenic (TG) mice harbouring a BAC carrying IG-DMR (intergenic-differentially methylated region), Gtl2-DMR, Gtl2, Rtl1/Rtl1as, and part of Rian.
      Title: Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice.
    9. Non-coding RNAs Meg8 and Irm as alternatively spliced isoforms of Rian gene might be coordinately expressed and functionally correlated in diverse organs.
      Title: Expression of macro non-coding RNAs Meg8 and Irm in mouse embryonic development.
    10. These results indicated that AB063319, as a stable transcriptional ncRNA, might play the important roles in the morphogenesis of diverse organs and tissues
      Title: Expression of non-coding RNA AB063319 derived from Rian gene during mouse development.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of hepatic stellate cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028261.1 RNA Sequence

      Status: PREDICTED

      Source sequence(s)
      AC152063

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      109570379..109628150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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