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    Sec63 SEC63 homolog, protein translocation regulator [ Mus musculus (house mouse) ]

    Gene ID: 140740, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sec63provided by MGI
    Official Full Name
    SEC63 homolog, protein translocation regulatorprovided by MGI
    Primary source
    MGI:MGI:2155302
    See related
    Ensembl:ENSMUSG00000019802 AllianceGenome:MGI:2155302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730478J10Rik
    Summary
    Predicted to enable protein transmembrane transporter activity. Acts upstream of or within liver development; nitrogen cycle metabolic process; and protein targeting to ER. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of Sec62/Sec63 complex. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and pancreas. Human ortholog(s) of this gene implicated in polycystic liver disease 2. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.6), bladder adult (RPKM 13.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sec63 in Genome Data Viewer
    Location:
    10 B2; 10 22.89 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (42637492..42708510)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (42761496..42832514)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:42418909-42419167 Neighboring gene STARR-seq mESC enhancer starr_26494 Neighboring gene osteopetrosis associated transmembrane protein 1 Neighboring gene predicted gene 15199 Neighboring gene STARR-seq mESC enhancer starr_26495 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:42582153-42582336 Neighboring gene predicted gene, 53623 Neighboring gene predicted gene, 34006 Neighboring gene Scm polycomb group protein like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Sec62/Sec63 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    translocation protein SEC63 homolog
    Names
    SEC63-like
    dnaJ homolog subfamily C member 23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359283.1NP_001346212.1  translocation protein SEC63 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AY024346, BC059816, BF472596, CN539237
      UniProtKB/TrEMBL
      Q80YG4
      Conserved Domains (3) summary
      smart00611
      Location:209714
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      pfam00226
      Location:104162
      DnaJ; DnaJ domain
      pfam14797
      Location:563632
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    2. NM_001359284.1NP_001346213.1  translocation protein SEC63 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AY024346, BC059816, BF472596
      UniProtKB/TrEMBL
      Q8K2U5
      Conserved Domains (2) summary
      smart00611
      Location:69575
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      pfam14797
      Location:424493
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    3. NM_001359285.1NP_001346214.1  translocation protein SEC63 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AY024346, BC059816, BF472596
      UniProtKB/TrEMBL
      Q8K2U5
      Conserved Domains (2) summary
      smart00611
      Location:69574
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      cl27511
      Location:310520
      Na_Ca_ex; Sodium/calcium exchanger protein
    4. NM_001359286.1NP_001346215.1  translocation protein SEC63 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK036629, AY024346, BC059816, BF472596
      Conserved Domains (2) summary
      cl22482
      Location:1349
      Sec63; Sec63 Brl domain
      cl27511
      Location:84295
      Na_Ca_ex; Sodium/calcium exchanger protein
    5. NM_153055.3NP_694695.3  translocation protein SEC63 homolog isoform 1

      See identical proteins and their annotated locations for NP_694695.3

      Status: VALIDATED

      Source sequence(s)
      AY024346, BC059816, BF472596
      Consensus CDS
      CCDS23815.1
      UniProtKB/Swiss-Prot
      E9QKG1, Q8VEB9, Q8VHE0
      UniProtKB/TrEMBL
      Q80YG4
      Related
      ENSMUSP00000019937.5, ENSMUST00000019937.5
      Conserved Domains (4) summary
      smart00611
      Location:209715
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      pfam00226
      Location:104162
      DnaJ; DnaJ domain
      pfam05285
      Location:563612
      SDA1; SDA1
      pfam14797
      Location:564633
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      42637492..42708510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)