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    Rnf20 ring finger protein 20 [ Mus musculus (house mouse) ]

    Gene ID: 109331, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnf20provided by MGI
    Official Full Name
    ring finger protein 20provided by MGI
    Primary source
    MGI:MGI:1925927
    See related
    Ensembl:ENSMUSG00000028309 AllianceGenome:MGI:1925927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4116; 4833430L21Rik
    Summary
    Enables chromatin binding activity and histone H2B C-terminal K residue ubiquitin ligase activity. Predicted to be involved in several processes, including positive regulation of transcription by RNA polymerase II; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RNF20 (ring finger protein 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 22.3), CNS E14 (RPKM 15.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rnf20 in Genome Data Viewer
    Location:
    4 B1; 4 26.69 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49632005..49656887)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49632005..49656887)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10187 Neighboring gene STARR-positive B cell enhancer ABC_E2112 Neighboring gene predicted gene, 33159 Neighboring gene predicted gene, 45952 Neighboring gene glutamate receptor ionotropic, NMDA3A Neighboring gene protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) Neighboring gene STARR-seq mESC enhancer starr_10189 Neighboring gene STARR-seq mESC enhancer starr_10190 Neighboring gene predicted gene, 25485

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4116

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2B C-terminal K residue ubiquitin ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H2B C-terminal K residue ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of HULC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of HULC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of HULC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase BRE1A
    Names
    BRE1-A
    RING-type E3 ubiquitin transferase BRE1A
    NP_001156735.1
    NP_001343330.1
    NP_892044.1
    XP_006537616.1
    XP_011248208.1
    XP_030108941.1
    XP_036019473.1
    XP_036019474.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163263.1NP_001156735.1  E3 ubiquitin-protein ligase BRE1A isoform 1

      See identical proteins and their annotated locations for NP_001156735.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK051278, AK139883, BF730643, BQ442966, CJ052397, CN531555, DV660388
      Consensus CDS
      CCDS18178.1
      UniProtKB/Swiss-Prot
      A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
      Related
      ENSMUSP00000128546.2, ENSMUST00000167496.8
      Conserved Domains (3) summary
      PTZ00121
      Location:320934
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:41394
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16704
      Location:918963
      RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
    2. NM_001356401.1NP_001343330.1  E3 ubiquitin-protein ligase BRE1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK053783, AK139883, AL732521, BF730643, BQ442966, CN531555, DV660388
      Conserved Domains (2) summary
      PTZ00121
      Location:75689
      PTZ00121; MAEBL; Provisional
      cd16704
      Location:673718
      RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
    3. NM_182999.2NP_892044.1  E3 ubiquitin-protein ligase BRE1A isoform 1

      See identical proteins and their annotated locations for NP_892044.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK053783, AK139883, BF730643, BQ442966, CJ052397, CN531555, DV660388
      Consensus CDS
      CCDS18178.1
      UniProtKB/Swiss-Prot
      A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
      Related
      ENSMUSP00000029989.5, ENSMUST00000029989.11
      Conserved Domains (3) summary
      PTZ00121
      Location:320934
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:41394
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16704
      Location:918963
      RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      49632005..49656887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537553.4XP_006537616.1  E3 ubiquitin-protein ligase BRE1A isoform X1

      See identical proteins and their annotated locations for XP_006537616.1

      UniProtKB/Swiss-Prot
      A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
      Conserved Domains (3) summary
      PTZ00121
      Location:320934
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:41394
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16704
      Location:918963
      RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
    2. XM_011249906.4XP_011248208.1  E3 ubiquitin-protein ligase BRE1A isoform X1

      See identical proteins and their annotated locations for XP_011248208.1

      UniProtKB/Swiss-Prot
      A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
      Conserved Domains (3) summary
      PTZ00121
      Location:320934
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:41394
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16704
      Location:918963
      RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
    3. XM_036163580.1XP_036019473.1  E3 ubiquitin-protein ligase BRE1A isoform X2

      Conserved Domains (2) summary
      PTZ00121
      Location:75689
      PTZ00121; MAEBL; Provisional
      cd16704
      Location:673718
      RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
    4. XM_036163581.1XP_036019474.1  E3 ubiquitin-protein ligase BRE1A isoform X3

      Conserved Domains (2) summary
      PTZ00121
      Location:51665
      PTZ00121; MAEBL; Provisional
      cd16704
      Location:649694
      RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
    5. XM_030253081.2XP_030108941.1  E3 ubiquitin-protein ligase BRE1A isoform X2

      Conserved Domains (2) summary
      PTZ00121
      Location:75689
      PTZ00121; MAEBL; Provisional
      cd16704
      Location:673718
      RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins