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    Ikbkg inhibitor of kappaB kinase gamma [ Mus musculus (house mouse) ]

    Gene ID: 16151, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ikbkgprovided by MGI
    Official Full Name
    inhibitor of kappaB kinase gammaprovided by MGI
    Primary source
    MGI:MGI:1338074
    See related
    Ensembl:ENSMUSG00000004221 AllianceGenome:MGI:1338074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NEMO; IKK[g]; 1110037D23Rik
    Summary
    Enables K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and signaling adaptor activity. Involved in several processes, including anoikis; canonical NF-kappaB signal transduction; and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Acts upstream of or within B cell homeostasis and positive regulation of canonical NF-kappaB signal transduction. Located in cytoplasm. Part of IkappaB kinase complex. Is expressed in early conceptus; genitourinary system; and musculature. Used to study Bloch-Sulzberger syndrome and steatotic liver disease. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; X-linked recessive disease (multiple); learning disability; and liver cancer. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E18 (RPKM 3.8), bladder adult (RPKM 3.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ikbkg in Genome Data Viewer
    Location:
    X A7.3; X 38.0 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73436883..73498013)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74393233..74456792)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene STARR-seq mESC enhancer starr_47367 Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene STARR-positive B cell enhancer ABC_E11050 Neighboring gene predicted gene, 54057 Neighboring gene CTAG2 like 1 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables K63-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables linear polyubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables linear polyubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of vesicle localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of IkappaB kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of IkappaB kinase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of IkappaB kinase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NF-kappa-B essential modulator
    Names
    I-kappa-B kinase subunit gamma
    IKK-gamma
    IKKAP1
    IKKG
    NF-kappa-B essential modifier
    ikB kinase subunit gamma
    ikB kinase-associated protein 1
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    inhibitor of nuclear factor kappa-B kinase subunit gamma
    mFIP-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136067.2NP_001129539.1  NF-kappa-B essential modulator isoform 3

      See identical proteins and their annotated locations for NP_001129539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AL669976, AY112937
      Consensus CDS
      CCDS53108.1
      UniProtKB/TrEMBL
      Q7TSS3
      Related
      ENSMUSP00000004330.4, ENSMUST00000004330.10
      Conserved Domains (4) summary
      cd09803
      Location:269355
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:67303
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:62128
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:404429
      zf_C2H2_10; C2H2 type zinc-finger
    2. NM_001161421.1NP_001154893.1  NF-kappa-B essential modulator isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.
      Source sequence(s)
      AK037020, AL669976, AY112937
      UniProtKB/TrEMBL
      Q7TSS3, Q8VC91
      Conserved Domains (3) summary
      cd09803
      Location:268354
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:62129
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:185297
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    3. NM_001161422.1NP_001154894.1  NF-kappa-B essential modulator isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AL669976, AY112937, CN701499
      Consensus CDS
      CCDS53109.1
      UniProtKB/TrEMBL
      E9Q2Y3
      Related
      ENSMUSP00000109765.3, ENSMUST00000114130.9
      Conserved Domains (3) summary
      cd09803
      Location:263349
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:56123
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:180292
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    4. NM_001161423.1NP_001154895.1  NF-kappa-B essential modulator isoform 1

      See identical proteins and their annotated locations for NP_001154895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, CJ099503, CN717929
      Consensus CDS
      CCDS41023.1
      UniProtKB/Swiss-Prot
      O88522, Q924H4
      Related
      ENSMUSP00000126770.2, ENSMUST00000164101.8
      Conserved Domains (4) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:49285
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:44110
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:386411
      zf_C2H2_10; C2H2 type zinc-finger
    5. NM_001161424.1NP_001154896.1  NF-kappa-B essential modulator isoform 2

      See identical proteins and their annotated locations for NP_001154896.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, CJ099503, CV556906
      Consensus CDS
      CCDS30233.1
      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000136573.2, ENSMUST00000180230.8
      Conserved Domains (4) summary
      cd09803
      Location:250336
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:49284
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:44110
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:385410
      zf_C2H2_10; C2H2 type zinc-finger
    6. NM_010547.2NP_034677.2  NF-kappa-B essential modulator isoform 1

      See identical proteins and their annotated locations for NP_034677.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
      Source sequence(s)
      AL669976, AY112937, BY768708
      Consensus CDS
      CCDS41023.1
      UniProtKB/Swiss-Prot
      O88522, Q924H4
      Related
      ENSMUSP00000109762.2, ENSMUST00000114127.8
      Conserved Domains (4) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:49285
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:44110
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:386411
      zf_C2H2_10; C2H2 type zinc-finger
    7. NM_178590.4NP_848705.1  NF-kappa-B essential modulator isoform 2

      See identical proteins and their annotated locations for NP_848705.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, BY768708
      Consensus CDS
      CCDS30233.1
      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000064017.4, ENSMUST00000064407.10
      Conserved Domains (4) summary
      cd09803
      Location:250336
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:49284
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:44110
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:385410
      zf_C2H2_10; C2H2 type zinc-finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      73436883..73498013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527848.5XP_006527911.1  NF-kappa-B essential modulator isoform X1

      See identical proteins and their annotated locations for XP_006527911.1

      UniProtKB/TrEMBL
      Q7TSS3
      Conserved Domains (4) summary
      cd09803
      Location:269355
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:67303
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:62128
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:404429
      zf_C2H2_10; C2H2 type zinc-finger
    2. XM_006527852.4XP_006527915.1  NF-kappa-B essential modulator isoform X3

      See identical proteins and their annotated locations for XP_006527915.1

      UniProtKB/Swiss-Prot
      O88522, Q924H4
      Conserved Domains (4) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:49285
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:44110
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:386411
      zf_C2H2_10; C2H2 type zinc-finger
    3. XM_006527853.5XP_006527916.1  NF-kappa-B essential modulator isoform X4

      See identical proteins and their annotated locations for XP_006527916.1

      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000109764.3, ENSMUST00000114129.9
      Conserved Domains (4) summary
      cd09803
      Location:250336
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:49284
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:44110
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:385410
      zf_C2H2_10; C2H2 type zinc-finger
    4. XM_006527847.5XP_006527910.1  NF-kappa-B essential modulator isoform X1

      See identical proteins and their annotated locations for XP_006527910.1

      UniProtKB/TrEMBL
      Q7TSS3
      Conserved Domains (4) summary
      cd09803
      Location:269355
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:67303
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:62128
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:404429
      zf_C2H2_10; C2H2 type zinc-finger
    5. XM_006527850.4XP_006527913.1  NF-kappa-B essential modulator isoform X3

      See identical proteins and their annotated locations for XP_006527913.1

      UniProtKB/Swiss-Prot
      O88522, Q924H4
      Related
      ENSMUSP00000109763.2, ENSMUST00000114128.8
      Conserved Domains (4) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:49285
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:44110
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:386411
      zf_C2H2_10; C2H2 type zinc-finger
    6. XM_006527851.4XP_006527914.1  NF-kappa-B essential modulator isoform X3

      See identical proteins and their annotated locations for XP_006527914.1

      UniProtKB/Swiss-Prot
      O88522, Q924H4
      Conserved Domains (4) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:49285
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:44110
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:386411
      zf_C2H2_10; C2H2 type zinc-finger
    7. XM_006527849.3XP_006527912.1  NF-kappa-B essential modulator isoform X2

      Conserved Domains (4) summary
      cd09803
      Location:257343
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:55291
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:50116
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:392417
      zf_C2H2_10; C2H2 type zinc-finger
    8. XM_011247527.4XP_011245829.1  NF-kappa-B essential modulator isoform X3

      See identical proteins and their annotated locations for XP_011245829.1

      UniProtKB/Swiss-Prot
      O88522, Q924H4
      Conserved Domains (4) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      TIGR02168
      Location:49285
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11577
      Location:44110
      NEMO; NF-kappa-B essential modulator NEMO
      pfam18414
      Location:386411
      zf_C2H2_10; C2H2 type zinc-finger