Cd79a CD79a molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cd79aprovided by RGD
Full Name: CD79a moleculeprovided by RGD
Primary source: RGD:6484896
See related: EnsemblRapid:ENSRNOG00000020125 AllianceGenome:RGD:6484896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd79al
Summary: Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in B cell differentiation and B cell proliferation. Predicted to act upstream of or within B cell receptor signaling pathway. Predicted to be located in external side of plasma membrane; membrane raft; and multivesicular body. Predicted to be part of IgM B cell receptor complex. Human ortholog(s) of this gene implicated in agammaglobulinemia 3. Orthologous to human CD79A (CD79a molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 345.2), Thymus (RPKM 52.2) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (89621460..89625813)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80493581..80497936)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (81763609..81768039)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of B cell receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of B cell receptor complex	ISO Inferred from Sequence Orthology more info
part_of IgM B cell receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-cell antigen receptor complex-associated protein alpha chain

Names: -cell antigen receptor complex-associated protein alpha chain-like; B-cell antigen receptor complex-associated protein alpha chain-like; CD79A antigen (immunoglobulin-associated alpha); Cd79a molecule, immunoglobulin-associated alpha; Cd79a molecule-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402547.1 → NP_001389476.1 B-cell antigen receptor complex-associated protein alpha chain precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6J922, F1MAC3

Related

ENSRNOP00000027254.6, ENSRNOT00000027254.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

89621460..89625813

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759062.2 → XP_008757284.2 B-cell antigen receptor complex-associated protein alpha chain isoform X1

UniProtKB/TrEMBL

A6J922

Conserved Domains (2) summary

smart00077
Location:150 → 170

ITAM; Immunoreceptor tyrosine-based activation motif

smart00409
Location:6 → 90

IG; Immunoglobulin