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    Arl13b ARF like GTPase 13B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304037, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arl13bprovided by RGD
    Official Full Name
    ARF like GTPase 13Bprovided by RGD
    Primary source
    RGD:1584979
    See related
    EnsemblRapid:ENSRNOG00000047194 AllianceGenome:RGD:1584979
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including nervous system development; non-motile cilium assembly; and receptor localization to non-motile cilium. Predicted to act upstream of or within dorsal/ventral pattern formation; heart looping; and left/right axis specification. Predicted to be located in axoneme. Predicted to be active in ciliary membrane; motile cilium; and non-motile cilium. Human ortholog(s) of this gene implicated in Joubert syndrome 8. Orthologous to human ARL13B (ADP ribosylation factor like GTPase 13B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 69.2), Kidney (RPKM 51.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arl13b in Genome Data Viewer
    Location:
    11p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (13597538..13663681, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (150100..217103, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (1122567..1188209, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene 5.8S ribosomal RNA Neighboring gene solute carrier family 22 (organic anion transporter), member 7, pseudogene 1 Neighboring gene syntaxin 19 Neighboring gene protein S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats. Jiang L, et al. Biochem Pharmacol, 2024 Sep. PMID 39038552
    2. Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. Thompson CL, et al. FASEB J, 2016 Feb. PMID 26499268
    3. Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts. Li Y, et al. J Am Soc Nephrol, 2016 Dec. PMID 27153923, Free PMC Article
    4. Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. Cantagrel V, et al. Am J Hum Genet, 2008 Aug. PMID 18674751, Free PMC Article
    5. A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice. Heydet D, et al. Dev Neurobiol, 2013 Jan. PMID 22581473

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats.
      Title: ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formation of radial glial scaffolds ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart looping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interneuron migration from the subpallium to the cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within left/right axis specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural tube patterning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor localization to non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 13B
    Names
    ADP-ribosylation factor like GTPase 13B
    ADP-ribosylation factor-like 13B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107101.1 → NP_001100571.1  ADP-ribosylation factor-like protein 13B

      See identical proteins and their annotated locations for NP_001100571.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474112
      UniProtKB/TrEMBL
      A6KSZ8, M0RDU9
      Related
      ENSRNOP00000067810.2, ENSRNOT00000074108.5
      Conserved Domains (2) summary
      cd04161
      Location:23 → 189
      Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13
      pfam00071
      Location:24 → 172
      Ras; Ras family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      13597538..13663681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240716.5 → XP_006240778.1  ADP-ribosylation factor-like protein 13B isoform X2

      Conserved Domains (2) summary
      cd04161
      Location:1 → 164
      Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13
      cl23809
      Location:390 → 450
      DUF4271; Domain of unknown function (DUF4271)

    2. XM_039088392.2 → XP_038944320.1  ADP-ribosylation factor-like protein 13B isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZXD0
      Related
      ENSRNOP00000084231.1, ENSRNOT00000099706.2
      Conserved Domains (1) summary
      cd04161
      Location:23 → 189
      Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13

    3. XM_039088391.2 → XP_038944319.1  ADP-ribosylation factor-like protein 13B isoform X1

      Conserved Domains (1) summary
      cd04161
      Location:23 → 189
      Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13
    Nucleotide Protein Strain
    Heading Accession and Version

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