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    Eaf2 ELL associated factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eaf2provided by RGD
    Official Full Name
    ELL associated factor 2provided by RGD
    Primary source
    RGD:628879
    See related
    EnsemblRapid:ENSRNOG00000002350 AllianceGenome:RGD:628879
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Traits
    Summary
    Predicted to enable transcription elongation factor activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II; regulation of transcription elongation by RNA polymerase II; and transcription elongation by RNA polymerase II. Predicted to act upstream of or within negative regulation of cell growth and negative regulation of epithelial cell proliferation involved in prostate gland development. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. Orthologous to human EAF2 (ELL associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 14.5), Kidney (RPKM 9.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eaf2 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (77465585..77509993)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63960200..64004610)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (66878658..66923092)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene golgin B1 Neighboring gene IQ motif containing B1 Neighboring gene solute carrier family 15 member 2 Neighboring gene RNA guanylyltransferase and 5'-phosphatase, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Xiao W, et al. Oncogene, 2008 Mar 6. PMID 17873910, Free PMC Article
    2. ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation. Xiao W, et al. Prostate, 2006 Jan 1. PMID 16114057
    3. Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer. Xiao W, et al. Cancer Res, 2003 Aug 1. PMID 12907652
    4. Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II. Saso K, et al. J Biochem, 2003 Apr. PMID 12761297
    5. The super elongation complex (SEC) family in transcriptional control. Luo Z, et al. Nat Rev Mol Cell Biol, 2012 Sep. PMID 22895430

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription elongation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of epithelial cell proliferation involved in prostate gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of super elongation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription elongation factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ELL-associated factor 2
    Names
    testosterone regulated apoptosis inducer and tumor suppressor
    testosterone-regulated apoptosis inducer and tumor suppressor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172047.1 → NP_742044.1  ELL-associated factor 2

      See identical proteins and their annotated locations for NP_742044.1

      Status: PROVISIONAL

      Source sequence(s)
      AY049022
      UniProtKB/Swiss-Prot
      Q811X5
      UniProtKB/TrEMBL
      A6IRB1
      Related
      ENSRNOP00000003208.5, ENSRNOT00000003208.7
      Conserved Domains (1) summary
      pfam09816
      Location:17 → 113
      EAF; RNA polymerase II transcription elongation factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      77465585..77509993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270315.1 → XP_063126385.1  ELL-associated factor 2 isoform X1

      UniProtKB/TrEMBL
      A6IRB3

    2. XM_039088054.2 → XP_038943982.1  ELL-associated factor 2 isoform X1

      UniProtKB/TrEMBL
      A6IRB3

    3. XM_039088053.2 → XP_038943981.1  ELL-associated factor 2 isoform X1

      UniProtKB/TrEMBL
      A6IRB3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q811X5.1 GenPept UniProtKB/Swiss-Prot:Q811X5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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