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    Rhobtb3 Rho-related BTB domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309922, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rhobtb3provided by RGD
    Official Full Name
    Rho-related BTB domain containing 3provided by RGD
    Primary source
    RGD:1311683
    See related
    EnsemblRapid:ENSRNOG00000012414 AllianceGenome:RGD:1311683
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and enzyme binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of proteolysis; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within male gonad development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human RHOBTB3 (Rho related BTB domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 150.3), Liver (RPKM 109.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhobtb3 in Genome Data Viewer
    Location:
    2q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (7094972..7201507, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (5363388..5419164, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (2627655..2683305, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase kappa 1-like Neighboring gene glutaredoxin Neighboring gene small nucleolar RNA SNORA17 Neighboring gene spermatogenesis associated 9 Neighboring gene Rieske (Fe-S) domain containing Neighboring gene G protein-coupled receptor 150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. Espinosa EJ, et al. Cell, 2009 May 29. PMID 19490898, Free PMC Article
    2. Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Lutz J, et al. Histochem Cell Biol, 2014 Nov. PMID 24923387
    3. MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. Schenková K, et al. J Mol Biol, 2012 Oct 5. PMID 22709582
    4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho-related BTB domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107645.1 → NP_001101115.1  rho-related BTB domain-containing protein 3

      See identical proteins and their annotated locations for NP_001101115.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473955
      UniProtKB/TrEMBL
      A6I4F2, A6I4F3, D3ZW90
      Related
      ENSRNOP00000016838.5, ENSRNOT00000016838.8
      Conserved Domains (3) summary
      smart00225
      Location:421 → 518
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:413 → 515
      BTB; BTB/POZ domain
      cl21455
      Location:34 → 174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      7094972..7201507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281692.1 → XP_063137762.1  rho-related BTB domain-containing protein 3 isoform X2

    2. XM_039102150.2 → XP_038958078.1  rho-related BTB domain-containing protein 3 isoform X1

      Conserved Domains (3) summary
      cd18357
      Location:236 → 393
      BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cl38908
      Location:410 → 428
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:34 → 174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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